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GABARAPL3 GABARAPL3 MAP1LC3C MAP1LC3C MAP1LC3A MAP1LC3A ATG4D ATG4D ATG3 ATG3 GABARAPL1 GABARAPL1 ATG7 ATG7 MAP1LC3B MAP1LC3B GABARAP GABARAP MAP1LC3B2 MAP1LC3B2 GABARAPL2 GABARAPL2
"ATG4D" - autophagy related 4D, cysteine peptidase in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
coexpression edge
co-expression
homology edge
protein homology
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ATG4Dautophagy related 4D, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes (474 aa)    
Predicted Functional Partners:
GABARAPL1
GABA(A) receptor-associated protein like 1; Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles (117 aa)
      score_image score_image   score_image   0.954
GABARAPL2
GABA(A) receptor-associated protein-like 2; Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (By similarity) (117 aa)
      score_image score_image   score_image   0.943
GABARAP
GABA(A) receptor-associated protein; May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity) (117 aa)
      score_image score_image   score_image   0.936
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma; Probably involved in formation of autophagosomal vacuoles (autophagosomes) (By similarity) (147 aa)
      score_image score_image   score_image   0.933
GABARAPL3
GABA(A) receptors associated protein like 3, pseudogene (117 aa)
      score_image score_image   score_image   0.928
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) (125 aa)
      score_image score_image   score_image   0.918
MAP1LC3B
microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) (125 aa)
      score_image score_image   score_image   0.916
ATG3
autophagy related 3; E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3 (314 aa)
      score_image score_image   score_image   0.906
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2; Probably involved in formation of autophagosomal vacuoles (autophagosomes) (By similarity) (125 aa)
      score_image score_image   score_image   0.874
ATG7
autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) (703 aa)
      score_image score_image   score_image   0.860
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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