node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AVL9 | DENND6A | ENSP00000315568 | ENSP00000311401 | AVL9 homolog (S. cerevisiase); Functions in cell migration | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | 0.861 |
AVL9 | FAM45A | ENSP00000315568 | ENSP00000354688 | AVL9 homolog (S. cerevisiase); Functions in cell migration | family with sequence similarity 45, member A | 0.861 |
AVL9 | KIAA1147 | ENSP00000315568 | ENSP00000445768 | AVL9 homolog (S. cerevisiase); Functions in cell migration | KIAA1147; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity) | 0.872 |
CYB561D1 | DENND6A | ENSP00000358884 | ENSP00000311401 | cytochrome b-561 domain containing 1 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | 0.502 |
CYB561D1 | ZSCAN29 | ENSP00000358884 | ENSP00000380174 | cytochrome b-561 domain containing 1 | zinc finger and SCAN domain containing 29; May be involved in transcriptional regulation | 0.626 |
DDI1 | DENND6A | ENSP00000302805 | ENSP00000311401 | DNA-damage inducible 1 homolog 1 (S. cerevisiae) | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | 0.414 |
DDI1 | FAM168B | ENSP00000302805 | ENSP00000374565 | DNA-damage inducible 1 homolog 1 (S. cerevisiae) | family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | 0.409 |
DENND6A | AVL9 | ENSP00000311401 | ENSP00000315568 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | AVL9 homolog (S. cerevisiase); Functions in cell migration | 0.861 |
DENND6A | CYB561D1 | ENSP00000311401 | ENSP00000358884 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | cytochrome b-561 domain containing 1 | 0.502 |
DENND6A | DDI1 | ENSP00000311401 | ENSP00000302805 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | DNA-damage inducible 1 homolog 1 (S. cerevisiae) | 0.414 |
DENND6A | DNAJB14 | ENSP00000311401 | ENSP00000404381 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | DnaJ (Hsp40) homolog, subfamily B, member 14; May act as a co-chaperone (By similarity) | 0.461 |
DENND6A | FAM160B1 | ENSP00000311401 | ENSP00000358251 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | family with sequence similarity 160, member B1 | 0.435 |
DENND6A | FAM168B | ENSP00000311401 | ENSP00000374565 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | 0.520 |
DENND6A | FAM45A | ENSP00000311401 | ENSP00000354688 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | family with sequence similarity 45, member A | 0.864 |
DENND6A | KIAA1147 | ENSP00000311401 | ENSP00000445768 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | KIAA1147; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity) | 0.868 |
DENND6A | UBE2QL1 | ENSP00000311401 | ENSP00000382713 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | ubiquitin-conjugating enzyme E2Q family-like 1; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential) | 0.416 |
DENND6A | ZSCAN29 | ENSP00000311401 | ENSP00000380174 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | zinc finger and SCAN domain containing 29; May be involved in transcriptional regulation | 0.565 |
DNAJB14 | DENND6A | ENSP00000404381 | ENSP00000311401 | DnaJ (Hsp40) homolog, subfamily B, member 14; May act as a co-chaperone (By similarity) | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | 0.461 |
DNAJB14 | FAM168B | ENSP00000404381 | ENSP00000374565 | DnaJ (Hsp40) homolog, subfamily B, member 14; May act as a co-chaperone (By similarity) | family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | 0.450 |
FAM160B1 | DENND6A | ENSP00000358251 | ENSP00000311401 | family with sequence similarity 160, member B1 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | 0.435 |