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STRINGSTRING
UBE2QL1 UBE2QL1 DNAJB14 DNAJB14 DDI1 DDI1 FAM168B FAM168B AVL9 AVL9 DENND6A DENND6A FAM160B1 FAM160B1 FAM45A FAM45A KIAA1147 KIAA1147 ZSCAN29 ZSCAN29 CYB561D1 CYB561D1
"DENND6A" - DENN/MADD domain containing 6A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Cooccurence
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Experiments
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[Homology]
Score
DENND6ADENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes (608 aa)    
Predicted Functional Partners:
KIAA1147
KIAA1147; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity) (455 aa)
            score_image   0.868
FAM45A
family with sequence similarity 45, member A (357 aa)
            score_image   0.864
AVL9
AVL9 homolog (S. cerevisiase); Functions in cell migration (648 aa)
            score_image   0.861
ZSCAN29
zinc finger and SCAN domain containing 29; May be involved in transcriptional regulation (852 aa)
            score_image   0.565
FAM168B
family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) (195 aa)
            score_image   0.520
CYB561D1
cytochrome b-561 domain containing 1 (251 aa)
            score_image   0.502
DNAJB14
DnaJ (Hsp40) homolog, subfamily B, member 14; May act as a co-chaperone (By similarity) (379 aa)
            score_image   0.461
FAM160B1
family with sequence similarity 160, member B1 (765 aa)
            score_image   0.435
UBE2QL1
ubiquitin-conjugating enzyme E2Q family-like 1; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential) (161 aa)
            score_image   0.416
DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae) (396 aa)
            score_image   0.414
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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