Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
ASB11 ASB11 DPPA3 DPPA3 ABLIM2 ABLIM2 ACTA1 ACTA1 DUSP28 DUSP28 ABRA ABRA ABLIM3 ABLIM3 ASB5 ASB5 SRF SRF ABLIM1 ABLIM1 PRDX3 PRDX3
"ABRA" - actin-binding Rho activating protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABRAactin-binding Rho activating protein; Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity) (381 aa)    
Predicted Functional Partners:
ABLIM2
actin binding LIM protein family, member 2 (645 aa)
        score_image   score_image   0.936
ABLIM1
actin binding LIM protein 1 (778 aa)
        score_image   score_image   0.936
ABLIM3
actin binding LIM protein family, member 3; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity (683 aa)
        score_image   score_image   0.936
PRDX3
peroxiredoxin 3; Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (256 aa)
      score_image     score_image   0.901
DUSP28
dual specificity phosphatase 28 (176 aa)
            score_image   0.758
DPPA3
developmental pluripotency associated 3; Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC- specifically recognizes and binds histone H3 dimethylated at ’Lys-9’ (H3K9me2) on matern [...] (159 aa)
            score_image   0.727
ACTA1
actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa)
        score_image   score_image   0.624
SRF
serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation (508 aa)
            score_image   0.601
ASB11
ankyrin repeat and SOCS box containing 11; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (323 aa)
      score_image     score_image   0.595
ASB5
ankyrin repeat and SOCS box containing 5; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis (By similarity) (329 aa)
            score_image   0.595
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (20%)