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ZC2HC1C ZC2HC1C HNRNPC HNRNPC PRC1 PRC1 SMARCD1 SMARCD1 KRT6A KRT6A MEAF6 MEAF6 CCDC85B CCDC85B LDOC1 LDOC1 MCRS1 MCRS1 STS STS NRIP1 NRIP1
"CCDC85B" - coiled-coil domain containing 85B in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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CCDC85Bcoiled-coil domain containing 85B; Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (202 aa)    
Predicted Functional Partners:
STS
steroid sulfatase (microsomal), isozyme S; Conversion of sulfated steroid precursors to estrogens during pregnancy (583 aa)
            score_image   0.751
MCRS1
microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (475 aa)
        score_image   score_image   0.728
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1; Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subuni [...] (515 aa)
        score_image       0.690
MEAF6
MYST/Esa1-associated factor 6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of [...] (201 aa)
        score_image       0.690
HNRNPC
heterogeneous nuclear ribonucleoprotein C (C1/C2) (306 aa)
        score_image   score_image   0.653
ZC2HC1C
zinc finger, C2HC-type containing 1C (456 aa)
        score_image       0.646
PRC1
protein regulator of cytokinesis 1; Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle (620 aa)
        score_image       0.646
KRT6A
keratin 6A (564 aa)
        score_image       0.646
NRIP1
nuclear receptor interacting protein 1; Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors (1158 aa)
        score_image       0.630
LDOC1
leucine zipper, down-regulated in cancer 1; May have an important role in the development and/or progression of some cancers (146 aa)
        score_image       0.624
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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