| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CARHSP1 | COPS7A | ENSP00000311847 | ENSP00000229251 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association w [...] | 0.625 |
| CARHSP1 | DDX6 | ENSP00000311847 | ENSP00000264018 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | DEAD (Asp-Glu-Ala-Asp) box helicase 6; In the process of mRNA degradation, may play a role in mRNA decapping | 0.676 |
| CARHSP1 | INS | ENSP00000311847 | ENSP00000250971 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.801 |
| CARHSP1 | KDM8 | ENSP00000311847 | ENSP00000398410 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | lysine (K)-specific demethylase 8; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation | 0.616 |
| CARHSP1 | PNPO | ENSP00000311847 | ENSP00000225573 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | pyridoxamine 5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP) | 0.627 |
| CARHSP1 | PPARA | ENSP00000311847 | ENSP00000262735 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerizati [...] | 0.800 |
| CARHSP1 | RPS6KA1 | ENSP00000311847 | ENSP00000435412 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 0.674 |
| CARHSP1 | SGK1 | ENSP00000311847 | ENSP00000356832 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | serum/glucocorticoid regulated kinase 1 | 0.605 |
| CARHSP1 | SLC38A7 | ENSP00000311847 | ENSP00000219320 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | solute carrier family 38, member 7; Mediates sodium-dependent transport of amino acids, preferentially L-glutamine (By similarity) | 0.660 |
| CARHSP1 | STYX | ENSP00000311847 | ENSP00000346599 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | serine/threonine/tyrosine interacting protein; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Seems to play a role in spermiogenesis (By similarity) | 0.931 |
| COPS7A | CARHSP1 | ENSP00000229251 | ENSP00000311847 | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association w [...] | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | 0.625 |
| COPS7A | KDM8 | ENSP00000229251 | ENSP00000398410 | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association w [...] | lysine (K)-specific demethylase 8; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation | 0.651 |
| COPS7A | PNPO | ENSP00000229251 | ENSP00000225573 | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association w [...] | pyridoxamine 5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP) | 0.496 |
| COPS7A | SLC38A7 | ENSP00000229251 | ENSP00000219320 | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association w [...] | solute carrier family 38, member 7; Mediates sodium-dependent transport of amino acids, preferentially L-glutamine (By similarity) | 0.706 |
| DDX6 | CARHSP1 | ENSP00000264018 | ENSP00000311847 | DEAD (Asp-Glu-Ala-Asp) box helicase 6; In the process of mRNA degradation, may play a role in mRNA decapping | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | 0.676 |
| INS | CARHSP1 | ENSP00000250971 | ENSP00000311847 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | 0.801 |
| INS | PPARA | ENSP00000250971 | ENSP00000262735 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerizati [...] | 0.973 |
| INS | RPS6KA1 | ENSP00000250971 | ENSP00000435412 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 0.516 |
| INS | SGK1 | ENSP00000250971 | ENSP00000356832 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | serum/glucocorticoid regulated kinase 1 | 0.992 |
| KDM8 | CARHSP1 | ENSP00000398410 | ENSP00000311847 | lysine (K)-specific demethylase 8; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | 0.616 |
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