UBXN2A protein (Homo sapiens) - STRING network view

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UBXN2A

UBX domain protein 2A (259 aa)

Predicted Functional Partners:

VCP

0.921

PLAA

0.831

AURKB

0.831

AURKC

0.831

AURKA

0.831

HSPA9

0.815

VCPIP1

0.767

UBC

0.754

YOD1

0.753

SPATA5L1

0.751

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AURKA	AURKB	ENSP00000216911	ENSP00000463999	aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...]	aurora kinase B	0.928
AURKA	UBC	ENSP00000216911	ENSP00000344818	aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...]	ubiquitin C	0.999
AURKA	UBXN2A	ENSP00000216911	ENSP00000312107	aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...]	UBX domain protein 2A	0.831
AURKB	AURKA	ENSP00000463999	ENSP00000216911	aurora kinase B	aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...]	0.928
AURKB	AURKC	ENSP00000463999	ENSP00000302898	aurora kinase B	aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...]	0.955
AURKB	UBC	ENSP00000463999	ENSP00000344818	aurora kinase B	ubiquitin C	0.999
AURKB	UBXN2A	ENSP00000463999	ENSP00000312107	aurora kinase B	UBX domain protein 2A	0.831
AURKC	AURKB	ENSP00000302898	ENSP00000463999	aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...]	aurora kinase B	0.955
AURKC	UBC	ENSP00000302898	ENSP00000344818	aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...]	ubiquitin C	0.802
AURKC	UBXN2A	ENSP00000302898	ENSP00000312107	aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...]	UBX domain protein 2A	0.831
HSPA9	UBC	ENSP00000297185	ENSP00000344818	heat shock 70kDa protein 9 (mortalin)	ubiquitin C	0.997
HSPA9	UBXN2A	ENSP00000297185	ENSP00000312107	heat shock 70kDa protein 9 (mortalin)	UBX domain protein 2A	0.815
HSPA9	VCP	ENSP00000297185	ENSP00000351777	heat shock 70kDa protein 9 (mortalin)	valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...]	0.411
PLAA	SPATA5L1	ENSP00000380460	ENSP00000305494	phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity)	spermatogenesis associated 5-like 1	0.949
PLAA	UBC	ENSP00000380460	ENSP00000344818	phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity)	ubiquitin C	0.999
PLAA	UBXN2A	ENSP00000380460	ENSP00000312107	phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity)	UBX domain protein 2A	0.831
PLAA	VCP	ENSP00000380460	ENSP00000351777	phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity)	valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...]	0.998
PLAA	YOD1	ENSP00000380460	ENSP00000326813	phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity)	YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae); Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of both ’Lys-48’- and ’Lys-63’-linked [...]	0.961
SPATA5L1	PLAA	ENSP00000305494	ENSP00000380460	spermatogenesis associated 5-like 1	phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity)	0.949
SPATA5L1	UBC	ENSP00000305494	ENSP00000344818	spermatogenesis associated 5-like 1	ubiquitin C	0.913

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