Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | BTN2A1 | butyrophilin, subfamily 2, member A1 (527 aa) | ||||||||||||
Predicted Functional Partners:
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 | TAPBPL | TAP binding protein-like (468 aa) |
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0.879 | ||||||||||
 | CD209 | CD209 molecule (404 aa) |
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0.826 | ||||||||||
 | UBC | ubiquitin C (685 aa) |
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0.721 | ||||||||||
 | TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain; Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed-9382840, it cannot but according to PubMed-9430226, it can induce the NF-kappa-B pathway (386 aa) |
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0.601 | ||||||||||
 | TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis (440 aa) |
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0.601 | ||||||||||
 | TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B (468 aa) |
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0.601 | ||||||||||
 | LYZL1 | lysozyme-like 1 (194 aa) |
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0.562 | ||||||||||
 | LYZL2 | lysozyme-like 2 (194 aa) |
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0.562 | ||||||||||
 | TCEB3 | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (798 aa) |
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0.530 | ||||||||||
 | NCALD | neurocalcin delta; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (193 aa) |
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0.522 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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