node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARV1 | ERN1 | ENSP00000312458 | ENSP00000401445 | ARV1 homolog (S. cerevisiae) | endoplasmic reticulum to nucleus signaling 1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis | 0.718 |
ARV1 | ERN2 | ENSP00000312458 | ENSP00000256797 | ARV1 homolog (S. cerevisiae) | endoplasmic reticulum to nucleus signaling 2; Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins | 0.695 |
ARV1 | FAT4 | ENSP00000312458 | ENSP00000377862 | ARV1 homolog (S. cerevisiae) | FAT tumor suppressor homolog 4 (Drosophila); May function in the regulation of planar cell polarity (By similarity). Cadherins are cell-cell interaction molecules (By similarity) | 0.578 |
ARV1 | JAG1 | ENSP00000312458 | ENSP00000254958 | ARV1 homolog (S. cerevisiae) | jagged 1; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro) | 0.745 |
ARV1 | PIGG | ENSP00000312458 | ENSP00000415203 | ARV1 homolog (S. cerevisiae) | phosphatidylinositol glycan anchor biosynthesis, class G | 0.820 |
ARV1 | PIGM | ENSP00000312458 | ENSP00000357069 | ARV1 homolog (S. cerevisiae) | phosphatidylinositol glycan anchor biosynthesis, class M; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly | 0.630 |
ARV1 | PIGO | ENSP00000312458 | ENSP00000339382 | ARV1 homolog (S. cerevisiae) | phosphatidylinositol glycan anchor biosynthesis, class O; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity) | 0.557 |
ARV1 | PIGW | ENSP00000312458 | ENSP00000332313 | ARV1 homolog (S. cerevisiae) | phosphatidylinositol glycan anchor biosynthesis, class W; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI- anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity) | 0.804 |
ARV1 | RNASEL | ENSP00000312458 | ENSP00000356530 | ARV1 homolog (S. cerevisiae) | ribonuclease L (2’,5’-oligoisoadenylate synthetase-dependent); Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosi [...] | 0.695 |
ARV1 | UBC | ENSP00000312458 | ENSP00000344818 | ARV1 homolog (S. cerevisiae) | ubiquitin C | 0.629 |
ERN1 | ARV1 | ENSP00000401445 | ENSP00000312458 | endoplasmic reticulum to nucleus signaling 1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis | ARV1 homolog (S. cerevisiae) | 0.718 |
ERN1 | UBC | ENSP00000401445 | ENSP00000344818 | endoplasmic reticulum to nucleus signaling 1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis | ubiquitin C | 0.844 |
ERN2 | ARV1 | ENSP00000256797 | ENSP00000312458 | endoplasmic reticulum to nucleus signaling 2; Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins | ARV1 homolog (S. cerevisiae) | 0.695 |
FAT4 | ARV1 | ENSP00000377862 | ENSP00000312458 | FAT tumor suppressor homolog 4 (Drosophila); May function in the regulation of planar cell polarity (By similarity). Cadherins are cell-cell interaction molecules (By similarity) | ARV1 homolog (S. cerevisiae) | 0.578 |
JAG1 | ARV1 | ENSP00000254958 | ENSP00000312458 | jagged 1; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro) | ARV1 homolog (S. cerevisiae) | 0.745 |
JAG1 | UBC | ENSP00000254958 | ENSP00000344818 | jagged 1; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro) | ubiquitin C | 0.990 |
PIGG | ARV1 | ENSP00000415203 | ENSP00000312458 | phosphatidylinositol glycan anchor biosynthesis, class G | ARV1 homolog (S. cerevisiae) | 0.820 |
PIGG | PIGM | ENSP00000415203 | ENSP00000357069 | phosphatidylinositol glycan anchor biosynthesis, class G | phosphatidylinositol glycan anchor biosynthesis, class M; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly | 0.647 |
PIGG | PIGO | ENSP00000415203 | ENSP00000339382 | phosphatidylinositol glycan anchor biosynthesis, class G | phosphatidylinositol glycan anchor biosynthesis, class O; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity) | 0.951 |
PIGG | PIGW | ENSP00000415203 | ENSP00000332313 | phosphatidylinositol glycan anchor biosynthesis, class G | phosphatidylinositol glycan anchor biosynthesis, class W; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI- anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity) | 0.720 |