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STRINGSTRING
RNASEL RNASEL ERN1 ERN1 ERN2 ERN2 UBC UBC JAG1 JAG1 ARV1 ARV1 FAT4 FAT4 PIGG PIGG PIGO PIGO PIGW PIGW PIGM PIGM
ARV1 homolog (S. cerevisiae) in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
ARV1ARV1 homolog (S. cerevisiae) (271 aa)    
Predicted Functional Partners:
PIGG
phosphatidylinositol glycan anchor biosynthesis, class G (983 aa)
        score_image   score_image   0.820
PIGW
phosphatidylinositol glycan anchor biosynthesis, class W; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI- anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity) (504 aa)
        score_image   score_image   0.804
JAG1
jagged 1; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro) (1218 aa)
            score_image   0.745
ERN1
endoplasmic reticulum to nucleus signaling 1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis (977 aa)
        score_image   score_image   0.718
RNASEL
ribonuclease L (2’,5’-oligoisoadenylate synthetase-dependent); Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosi [...] (741 aa)
        score_image   score_image   0.695
ERN2
endoplasmic reticulum to nucleus signaling 2; Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins (974 aa)
        score_image       0.695
PIGM
phosphatidylinositol glycan anchor biosynthesis, class M; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (423 aa)
            score_image   0.630
UBC
ubiquitin C (685 aa)
        score_image       0.629
FAT4
FAT tumor suppressor homolog 4 (Drosophila); May function in the regulation of planar cell polarity (By similarity). Cadherins are cell-cell interaction molecules (By similarity) (4981 aa)
            score_image   0.578
PIGO
phosphatidylinositol glycan anchor biosynthesis, class O; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity) (1089 aa)
        score_image   score_image   0.557
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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