FAM109B protein (Homo sapiens) - STRING network view

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FAM109B

family with sequence similarity 109, member B; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane (259 aa)

Predicted Functional Partners:

OCRL

0.717

FAM183B

0.581

CATSPERD

0.581

FAM71B

0.580

PRR18

0.533

INPP5B

0.501

SFT2D1

0.501

PLEKHG2

0.456

CD163L1

0.424

SLC16A14

0.414

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CATSPERD	CD163L1	ENSP00000371037	ENSP00000315945	catsper channel auxiliary subunit delta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (By similarity)	CD163 molecule-like 1	0.499
CATSPERD	FAM109B	ENSP00000371037	ENSP00000312753	catsper channel auxiliary subunit delta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (By similarity)	family with sequence similarity 109, member B; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane	0.581
CATSPERD	FAM183B	ENSP00000371037	ENSP00000386657	catsper channel auxiliary subunit delta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (By similarity)	family with sequence similarity 183, member B	0.633
CATSPERD	FAM71B	ENSP00000371037	ENSP00000305596	catsper channel auxiliary subunit delta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (By similarity)	family with sequence similarity 71, member B; May be involved in RNA biogenesis	0.631
CD163L1	CATSPERD	ENSP00000315945	ENSP00000371037	CD163 molecule-like 1	catsper channel auxiliary subunit delta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (By similarity)	0.499
CD163L1	FAM109B	ENSP00000315945	ENSP00000312753	CD163 molecule-like 1	family with sequence similarity 109, member B; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane	0.424
CD163L1	FAM183B	ENSP00000315945	ENSP00000386657	CD163 molecule-like 1	family with sequence similarity 183, member B	0.499
CD163L1	FAM71B	ENSP00000315945	ENSP00000305596	CD163 molecule-like 1	family with sequence similarity 71, member B; May be involved in RNA biogenesis	0.480
FAM109B	CATSPERD	ENSP00000312753	ENSP00000371037	family with sequence similarity 109, member B; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane	catsper channel auxiliary subunit delta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (By similarity)	0.581
FAM109B	CD163L1	ENSP00000312753	ENSP00000315945	family with sequence similarity 109, member B; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane	CD163 molecule-like 1	0.424
FAM109B	FAM183B	ENSP00000312753	ENSP00000386657	family with sequence similarity 109, member B; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane	family with sequence similarity 183, member B	0.581
FAM109B	FAM71B	ENSP00000312753	ENSP00000305596	family with sequence similarity 109, member B; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane	family with sequence similarity 71, member B; May be involved in RNA biogenesis	0.580
FAM109B	INPP5B	ENSP00000312753	ENSP00000362115	family with sequence similarity 109, member B; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane	inositol polyphosphate-5-phosphatase, 75kDa	0.501
FAM109B	OCRL	ENSP00000312753	ENSP00000360154	family with sequence similarity 109, member B; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane	oculocerebrorenal syndrome of Lowe	0.717
FAM109B	PLEKHG2	ENSP00000312753	ENSP00000386733	family with sequence similarity 109, member B; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane	pleckstrin homology domain containing, family G (with RhoGef domain) member 2; May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide- binding protein (G protein)	0.456
FAM109B	PRR18	ENSP00000312753	ENSP00000319590	family with sequence similarity 109, member B; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane	proline rich 18	0.533
FAM109B	SFT2D1	ENSP00000312753	ENSP00000354590	family with sequence similarity 109, member B; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane	SFT2 domain containing 1; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex (By similarity)	0.501
FAM109B	SLC16A14	ENSP00000312753	ENSP00000295190	family with sequence similarity 109, member B; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane	solute carrier family 16, member 14 (monocarboxylic acid transporter 14); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity)	0.414
FAM183B	CATSPERD	ENSP00000386657	ENSP00000371037	family with sequence similarity 183, member B	catsper channel auxiliary subunit delta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (By similarity)	0.633
FAM183B	CD163L1	ENSP00000386657	ENSP00000315945	family with sequence similarity 183, member B	CD163 molecule-like 1	0.499

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