IFT80 protein (Homo sapiens) - STRING network view

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IFT80

intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia (777 aa)

Predicted Functional Partners:

IFT52

0.867

DYNC2H1

0.866

IFT88

0.846

IFT46

0.843

IFT57

0.842

IFT140

0.841

WDR19

0.802

CLUAP1

0.759

IFT27

0.729

IFT122

0.719

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLUAP1	IFT140	ENSP00000460850	ENSP00000406012	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	0.403
CLUAP1	IFT46	ENSP00000460850	ENSP00000264020	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)	0.535
CLUAP1	IFT52	ENSP00000460850	ENSP00000362121	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	intraflagellar transport 52 homolog (Chlamydomonas)	0.678
CLUAP1	IFT57	ENSP00000460850	ENSP00000264538	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear	0.687
CLUAP1	IFT80	ENSP00000460850	ENSP00000312778	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia	0.759
CLUAP1	IFT88	ENSP00000460850	ENSP00000323580	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	intraflagellar transport 88 homolog (Chlamydomonas); Involved in primary cilium biogenesis (By similarity)	0.469
DYNC2H1	IFT122	ENSP00000381167	ENSP00000296266	dynein, cytoplasmic 2, heavy chain 1	intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity)	0.458
DYNC2H1	IFT140	ENSP00000381167	ENSP00000406012	dynein, cytoplasmic 2, heavy chain 1	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	0.694
DYNC2H1	IFT27	ENSP00000381167	ENSP00000393541	dynein, cytoplasmic 2, heavy chain 1	intraflagellar transport 27 homolog (Chlamydomonas); Possesses GTPase activity (By similarity)	0.411
DYNC2H1	IFT46	ENSP00000381167	ENSP00000264020	dynein, cytoplasmic 2, heavy chain 1	intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)	0.683
DYNC2H1	IFT52	ENSP00000381167	ENSP00000362121	dynein, cytoplasmic 2, heavy chain 1	intraflagellar transport 52 homolog (Chlamydomonas)	0.712
DYNC2H1	IFT57	ENSP00000381167	ENSP00000264538	dynein, cytoplasmic 2, heavy chain 1	intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear	0.615
DYNC2H1	IFT80	ENSP00000381167	ENSP00000312778	dynein, cytoplasmic 2, heavy chain 1	intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia	0.866
DYNC2H1	IFT88	ENSP00000381167	ENSP00000323580	dynein, cytoplasmic 2, heavy chain 1	intraflagellar transport 88 homolog (Chlamydomonas); Involved in primary cilium biogenesis (By similarity)	0.784
DYNC2H1	WDR19	ENSP00000381167	ENSP00000382717	dynein, cytoplasmic 2, heavy chain 1	WD repeat domain 19; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in cilia function and/or assembly (By similarity)	0.732
IFT122	DYNC2H1	ENSP00000296266	ENSP00000381167	intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity)	dynein, cytoplasmic 2, heavy chain 1	0.458
IFT122	IFT140	ENSP00000296266	ENSP00000406012	intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity)	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	0.975
IFT122	IFT27	ENSP00000296266	ENSP00000393541	intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity)	intraflagellar transport 27 homolog (Chlamydomonas); Possesses GTPase activity (By similarity)	0.812
IFT122	IFT46	ENSP00000296266	ENSP00000264020	intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity)	intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)	0.625
IFT122	IFT52	ENSP00000296266	ENSP00000362121	intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity)	intraflagellar transport 52 homolog (Chlamydomonas)	0.850

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