node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDX23 | PRPF4B | ENSP00000310723 | ENSP00000337194 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | PRP4 pre-mRNA processing factor 4 homolog B (yeast); Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF | 0.610 |
DDX23 | PRPF6 | ENSP00000310723 | ENSP00000266079 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | 0.953 |
DDX23 | PRPF8 | ENSP00000310723 | ENSP00000304350 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.995 |
DDX23 | SART1 | ENSP00000310723 | ENSP00000310448 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | squamous cell carcinoma antigen recognized by T cells; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA | 0.813 |
DDX23 | SART3 | ENSP00000310723 | ENSP00000228284 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | squamous cell carcinoma antigen recognized by T cells 3; Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication | 0.583 |
DDX23 | SNRNP40 | ENSP00000310723 | ENSP00000263694 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | small nuclear ribonucleoprotein 40kDa (U5); Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs | 0.960 |
DDX23 | SRSF11 | ENSP00000310723 | ENSP00000359988 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing | 0.903 |
DDX23 | TXNL4A | ENSP00000310723 | ENSP00000269601 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | thioredoxin-like 4A; Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly | 0.950 |
DDX23 | USP39 | ENSP00000310723 | ENSP00000312981 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | ubiquitin specific peptidase 39 | 0.987 |
PRPF4B | DDX23 | ENSP00000337194 | ENSP00000310723 | PRP4 pre-mRNA processing factor 4 homolog B (yeast); Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | 0.610 |
PRPF4B | PRPF6 | ENSP00000337194 | ENSP00000266079 | PRP4 pre-mRNA processing factor 4 homolog B (yeast); Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | 0.925 |
PRPF4B | PRPF8 | ENSP00000337194 | ENSP00000304350 | PRP4 pre-mRNA processing factor 4 homolog B (yeast); Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.959 |
PRPF4B | SART1 | ENSP00000337194 | ENSP00000310448 | PRP4 pre-mRNA processing factor 4 homolog B (yeast); Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF | squamous cell carcinoma antigen recognized by T cells; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA | 0.659 |
PRPF4B | SNRNP40 | ENSP00000337194 | ENSP00000263694 | PRP4 pre-mRNA processing factor 4 homolog B (yeast); Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF | small nuclear ribonucleoprotein 40kDa (U5); Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs | 0.558 |
PRPF4B | USP39 | ENSP00000337194 | ENSP00000312981 | PRP4 pre-mRNA processing factor 4 homolog B (yeast); Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF | ubiquitin specific peptidase 39 | 0.994 |
PRPF6 | DDX23 | ENSP00000266079 | ENSP00000310723 | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | 0.953 |
PRPF6 | PRPF4B | ENSP00000266079 | ENSP00000337194 | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | PRP4 pre-mRNA processing factor 4 homolog B (yeast); Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF | 0.925 |
PRPF6 | PRPF8 | ENSP00000266079 | ENSP00000304350 | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.999 |
PRPF6 | SART1 | ENSP00000266079 | ENSP00000310448 | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | squamous cell carcinoma antigen recognized by T cells; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA | 0.999 |
PRPF6 | SART3 | ENSP00000266079 | ENSP00000228284 | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | squamous cell carcinoma antigen recognized by T cells 3; Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication | 0.909 |