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STRINGSTRING
PRPF4B PRPF4B PRPF8 PRPF8 DDX23 DDX23 SART1 SART1 PRPF6 PRPF6 SRSF11 SRSF11 USP39 USP39 TXNL4A TXNL4A SNRNP40 SNRNP40 SART3 SART3 SNRNP27 SNRNP27
"USP39" - ubiquitin specific peptidase 39 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
USP39ubiquitin specific peptidase 39 (565 aa)    
Predicted Functional Partners:
SNRNP27
small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing (155 aa)
        score_image   score_image   0.998
PRPF4B
PRP4 pre-mRNA processing factor 4 homolog B (yeast); Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (1007 aa)
      score_image score_image   score_image   0.994
SNRNP40
small nuclear ribonucleoprotein 40kDa (U5); Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs (357 aa)
      score_image score_image   score_image   0.993
TXNL4A
thioredoxin-like 4A; Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly (142 aa)
        score_image   score_image   0.987
PRPF6
PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) (941 aa)
        score_image   score_image   0.987
PRPF8
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site (2335 aa)
        score_image   score_image   0.987
DDX23
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (820 aa)
        score_image       0.987
SART3
squamous cell carcinoma antigen recognized by T cells 3; Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication (963 aa)
        score_image   score_image   0.940
SART1
squamous cell carcinoma antigen recognized by T cells; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA (800 aa)
        score_image   score_image   0.925
SRSF11
serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing (484 aa)
        score_image   score_image   0.912
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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