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STRINGSTRING
ANKFY1 ANKFY1 SEC14L1 SEC14L1 CHCHD10 CHCHD10 OSBPL10 OSBPL10 KEAP1 KEAP1 NIPSNAP1 NIPSNAP1 GBAS GBAS CHCHD1 CHCHD1 HADH HADH METTL17 METTL17 HADHA HADHA
"GBAS" - glioblastoma amplified sequence in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GBASglioblastoma amplified sequence (286 aa)    
Predicted Functional Partners:
OSBPL10
oxysterol binding protein-like 10 (764 aa)
        score_image       0.999
KEAP1
kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (624 aa)
        score_image       0.950
NIPSNAP1
nipsnap homolog 1 (C. elegans) (284 aa)
        score_image   score_image score_image 0.939
ANKFY1
ankyrin repeat and FYVE domain containing 1 (1170 aa)
        score_image   score_image   0.738
HADH
hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA (331 aa)
        score_image   score_image   0.701
HADHA
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit (763 aa)
        score_image       0.692
CHCHD10
coiled-coil-helix-coiled-coil-helix domain containing 10 (142 aa)
            score_image   0.599
SEC14L1
SEC14-like 1 (S. cerevisiae) (719 aa)
            score_image   0.562
CHCHD1
coiled-coil-helix-coiled-coil-helix domain containing 1 (118 aa)
            score_image   0.552
METTL17
methyltransferase like 17; May be a component of the mitochondrial small ribosomal subunit (By similarity) (478 aa)
            score_image   0.531
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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