SNX14 protein (Homo sapiens) - STRING network view

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Score

SNX14

sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity) (946 aa)

Predicted Functional Partners:

UBC

0.897

ZNF669

0.720

ZNF529

0.581

HNF1A

0.575

KANK1

0.573

DAPP1

0.503

SNX27

0.484

ACER3

0.458

PLEKHF1

0.455

PLEKHF2

0.455

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACER3	SNX14	ENSP00000434480	ENSP00000313121	alkaline ceramidase 3; Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	0.458
DAPP1	SNX14	ENSP00000423602	ENSP00000313121	dual adaptor of phosphotyrosine and 3-phosphoinositides; May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	0.503
HNF1A	SNX14	ENSP00000257555	ENSP00000313121	HNF1 homeobox A; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5’- GTTAATNATTAAC-3’	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	0.575
KANK1	SNX14	ENSP00000371734	ENSP00000313121	KN motif and ankyrin repeat domains 1; Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell sp [...]	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	0.573
KANK1	ZNF669	ENSP00000371734	ENSP00000342818	KN motif and ankyrin repeat domains 1; Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell sp [...]	zinc finger protein 669; May be involved in transcriptional regulation	0.610
PLEKHF1	SNX14	ENSP00000389787	ENSP00000313121	pleckstrin homology domain containing, family F (with FYVE domain) member 1; May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	0.455
PLEKHF1	UBC	ENSP00000389787	ENSP00000344818	pleckstrin homology domain containing, family F (with FYVE domain) member 1; May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8	ubiquitin C	0.494
PLEKHF2	SNX14	ENSP00000322373	ENSP00000313121	pleckstrin homology domain containing, family F (with FYVE domain) member 2	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	0.455
PLEKHF2	UBC	ENSP00000322373	ENSP00000344818	pleckstrin homology domain containing, family F (with FYVE domain) member 2	ubiquitin C	0.463
SNX14	ACER3	ENSP00000313121	ENSP00000434480	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	alkaline ceramidase 3; Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity	0.458
SNX14	DAPP1	ENSP00000313121	ENSP00000423602	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	dual adaptor of phosphotyrosine and 3-phosphoinositides; May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K	0.503
SNX14	HNF1A	ENSP00000313121	ENSP00000257555	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	HNF1 homeobox A; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5’- GTTAATNATTAAC-3’	0.575
SNX14	KANK1	ENSP00000313121	ENSP00000371734	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	KN motif and ankyrin repeat domains 1; Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell sp [...]	0.573
SNX14	PLEKHF1	ENSP00000313121	ENSP00000389787	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	pleckstrin homology domain containing, family F (with FYVE domain) member 1; May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8	0.455
SNX14	PLEKHF2	ENSP00000313121	ENSP00000322373	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	pleckstrin homology domain containing, family F (with FYVE domain) member 2	0.455
SNX14	SNX27	ENSP00000313121	ENSP00000357836	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	sorting nexin family member 27	0.484
SNX14	UBC	ENSP00000313121	ENSP00000344818	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	ubiquitin C	0.897
SNX14	ZNF529	ENSP00000313121	ENSP00000465578	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	zinc finger protein 529; May be involved in transcriptional regulation	0.581
SNX14	ZNF669	ENSP00000313121	ENSP00000342818	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	zinc finger protein 669; May be involved in transcriptional regulation	0.720
SNX27	SNX14	ENSP00000357836	ENSP00000313121	sorting nexin family member 27	sorting nexin 14; May be involved in several stages of intracellular trafficking (By similarity)	0.484

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