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PABPC1 PABPC1 EIF4G1 EIF4G1 HNRNPD HNRNPD HNRNPA1 HNRNPA1 PTBP1 PTBP1 HNRNPC HNRNPC UBC UBC HNRNPH1 HNRNPH1 YBX1 YBX1 HNRNPF HNRNPF HNRNPL HNRNPL
"HNRNPD" - heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) in Homo sapiens
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) (355 aa)    
Predicted Functional Partners:
PTBP1
polypyrimidine tract binding protein 1; Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (557 aa)
        score_image score_image score_image   0.999
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.999
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) (449 aa)
      score_image score_image score_image score_image   0.997
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome (1606 aa)
      score_image score_image   score_image   0.996
YBX1
Y box binding protein 1; Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at ’Lys-6’ and ’Lys-7’. Binds to promoters that contain a Y-box (5’-CTGATTGGCCAA-3’), such as MD [...] (324 aa)
      score_image score_image score_image score_image   0.995
HNRNPC
heterogeneous nuclear ribonucleoprotein C (C1/C2) (306 aa)
        score_image score_image score_image   0.995
HNRNPA1
heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication (372 aa)
      score_image score_image score_image score_image score_image 0.994
HNRNPL
heterogeneous nuclear ribonucleoprotein L; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (589 aa)
        score_image score_image score_image   0.994
HNRNPF
heterogeneous nuclear ribonucleoprotein F; Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (415 aa)
      score_image score_image score_image score_image   0.994
PABPC1
poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre- mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability [...] (636 aa)
      score_image score_image   score_image score_image 0.993
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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