ZNF541 protein (Homo sapiens) - STRING network view

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ZNF541

zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity) (1365 aa)

Predicted Functional Partners:

DNTTIP1

0.737

BRPF1

0.584

TMEM143

0.582

SPATA19

0.565

PNMAL2

0.563

XRN1

0.543

SPATA4

0.536

CATSPER3

0.503

KDM2A

0.501

FBXL19

0.501

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRPF1	ZNF541	ENSP00000373340	ENSP00000313258	bromodomain and PHD finger containing, 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2	zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity)	0.584
CATSPER3	SPATA19	ENSP00000282611	ENSP00000299140	cation channel, sperm associated 3; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...]	spermatogenesis associated 19; May have a role in spermiogenesis	0.418
CATSPER3	SPATA4	ENSP00000282611	ENSP00000280191	cation channel, sperm associated 3; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...]	spermatogenesis associated 4	0.406
CATSPER3	ZNF541	ENSP00000282611	ENSP00000313258	cation channel, sperm associated 3; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...]	zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity)	0.503
DNTTIP1	ZNF541	ENSP00000361705	ENSP00000313258	deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro	zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity)	0.737
FBXL19	ZNF541	ENSP00000369666	ENSP00000313258	F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity)	zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity)	0.501
KDM2A	ZNF541	ENSP00000432786	ENSP00000313258	lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...]	zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity)	0.501
PNMAL2	TMEM143	ENSP00000473036	ENSP00000293261	paraneoplastic Ma antigen family-like 2	transmembrane protein 143	0.560
PNMAL2	ZNF541	ENSP00000473036	ENSP00000313258	paraneoplastic Ma antigen family-like 2	zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity)	0.563
SPATA19	CATSPER3	ENSP00000299140	ENSP00000282611	spermatogenesis associated 19; May have a role in spermiogenesis	cation channel, sperm associated 3; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...]	0.418
SPATA19	SPATA4	ENSP00000299140	ENSP00000280191	spermatogenesis associated 19; May have a role in spermiogenesis	spermatogenesis associated 4	0.475
SPATA19	ZNF541	ENSP00000299140	ENSP00000313258	spermatogenesis associated 19; May have a role in spermiogenesis	zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity)	0.565
SPATA4	CATSPER3	ENSP00000280191	ENSP00000282611	spermatogenesis associated 4	cation channel, sperm associated 3; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...]	0.406
SPATA4	SPATA19	ENSP00000280191	ENSP00000299140	spermatogenesis associated 4	spermatogenesis associated 19; May have a role in spermiogenesis	0.475
SPATA4	ZNF541	ENSP00000280191	ENSP00000313258	spermatogenesis associated 4	zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity)	0.536
TMEM143	PNMAL2	ENSP00000293261	ENSP00000473036	transmembrane protein 143	paraneoplastic Ma antigen family-like 2	0.560
TMEM143	ZNF541	ENSP00000293261	ENSP00000313258	transmembrane protein 143	zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity)	0.582
XRN1	ZNF541	ENSP00000264951	ENSP00000313258	5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)	zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity)	0.543
ZNF541	BRPF1	ENSP00000313258	ENSP00000373340	zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity)	bromodomain and PHD finger containing, 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2	0.584
ZNF541	CATSPER3	ENSP00000313258	ENSP00000282611	zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity)	cation channel, sperm associated 3; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...]	0.503

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