| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC73 | HEPHL1 | ENSP00000335325 | ENSP00000313699 | coiled-coil domain containing 73 | hephaestin-like 1; May function as a ferroxidase and may be involved in copper transport and homeostasis (By similarity) | 0.561 |
| CYBB | HEPHL1 | ENSP00000367851 | ENSP00000313699 | cytochrome b-245, beta polypeptide; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc | hephaestin-like 1; May function as a ferroxidase and may be involved in copper transport and homeostasis (By similarity) | 0.512 |
| CYBB | NOX1 | ENSP00000367851 | ENSP00000362057 | cytochrome b-245, beta polypeptide; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc | NADPH oxidase 1; NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain | 0.724 |
| CYBB | NOX4 | ENSP00000367851 | ENSP00000263317 | cytochrome b-245, beta polypeptide; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc | NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displa [...] | 0.424 |
| CYBB | SLC11A2 | ENSP00000367851 | ENSP00000378364 | cytochrome b-245, beta polypeptide; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 0.483 |
| DUOX1 | HEPHL1 | ENSP00000317997 | ENSP00000313699 | dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain | hephaestin-like 1; May function as a ferroxidase and may be involved in copper transport and homeostasis (By similarity) | 0.512 |
| DUOX1 | SLC11A2 | ENSP00000317997 | ENSP00000378364 | dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 0.483 |
| DUOX1 | SOD3 | ENSP00000317997 | ENSP00000371554 | dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain | superoxide dismutase 3, extracellular; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen | 0.499 |
| DUOX2 | HEPHL1 | ENSP00000373691 | ENSP00000313699 | dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain | hephaestin-like 1; May function as a ferroxidase and may be involved in copper transport and homeostasis (By similarity) | 0.512 |
| DUOX2 | SLC11A2 | ENSP00000373691 | ENSP00000378364 | dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 0.483 |
| DUOX2 | SOD3 | ENSP00000373691 | ENSP00000371554 | dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain | superoxide dismutase 3, extracellular; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen | 0.443 |
| FXN | HEPHL1 | ENSP00000366482 | ENSP00000313699 | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | hephaestin-like 1; May function as a ferroxidase and may be involved in copper transport and homeostasis (By similarity) | 0.645 |
| FXN | SLC11A2 | ENSP00000366482 | ENSP00000378364 | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 0.426 |
| HEPHL1 | CCDC73 | ENSP00000313699 | ENSP00000335325 | hephaestin-like 1; May function as a ferroxidase and may be involved in copper transport and homeostasis (By similarity) | coiled-coil domain containing 73 | 0.561 |
| HEPHL1 | CYBB | ENSP00000313699 | ENSP00000367851 | hephaestin-like 1; May function as a ferroxidase and may be involved in copper transport and homeostasis (By similarity) | cytochrome b-245, beta polypeptide; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc | 0.512 |
| HEPHL1 | DUOX1 | ENSP00000313699 | ENSP00000317997 | hephaestin-like 1; May function as a ferroxidase and may be involved in copper transport and homeostasis (By similarity) | dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain | 0.512 |
| HEPHL1 | DUOX2 | ENSP00000313699 | ENSP00000373691 | hephaestin-like 1; May function as a ferroxidase and may be involved in copper transport and homeostasis (By similarity) | dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain | 0.512 |
| HEPHL1 | FXN | ENSP00000313699 | ENSP00000366482 | hephaestin-like 1; May function as a ferroxidase and may be involved in copper transport and homeostasis (By similarity) | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | 0.645 |
| HEPHL1 | NOX1 | ENSP00000313699 | ENSP00000362057 | hephaestin-like 1; May function as a ferroxidase and may be involved in copper transport and homeostasis (By similarity) | NADPH oxidase 1; NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain | 0.512 |
| HEPHL1 | NOX4 | ENSP00000313699 | ENSP00000263317 | hephaestin-like 1; May function as a ferroxidase and may be involved in copper transport and homeostasis (By similarity) | NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displa [...] | 0.512 |
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