AMBN protein (Homo sapiens) - STRING network view

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AMBN

ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel (447 aa)

Predicted Functional Partners:

ENAM

0.901

MSX2

0.896

RHOA

0.894

MMP20

0.870

AMTN

0.860

AMELX

0.811

TUFT1

0.759

BMP3

0.743

DSPP

0.729

KLK4

0.700

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBN	AMELX	ENSP00000313809	ENSP00000370088	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	0.811
AMBN	AMTN	ENSP00000313809	ENSP00000341013	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	0.860
AMBN	BMP3	ENSP00000313809	ENSP00000282701	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	bone morphogenetic protein 3; Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification	0.743
AMBN	DSPP	ENSP00000313809	ENSP00000282478	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	dentin sialophosphoprotein; DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals	0.729
AMBN	ENAM	ENSP00000313809	ENSP00000379383	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation	0.901
AMBN	KLK4	ENSP00000313809	ENSP00000326159	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	kallikrein-related peptidase 4; Involved in enamel formation	0.700
AMBN	MMP20	ENSP00000313809	ENSP00000260228	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation	0.870
AMBN	MSX2	ENSP00000313809	ENSP00000239243	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	msh homeobox 2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter	0.896
AMBN	RHOA	ENSP00000313809	ENSP00000400175	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...]	0.894
AMBN	TUFT1	ENSP00000313809	ENSP00000357842	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	tuftelin 1; Involved in the mineralization and structural organization of enamel	0.759
AMELX	AMBN	ENSP00000370088	ENSP00000313809	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	0.811
AMELX	AMTN	ENSP00000370088	ENSP00000341013	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	0.758
AMELX	DSPP	ENSP00000370088	ENSP00000282478	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	dentin sialophosphoprotein; DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals	0.457
AMELX	ENAM	ENSP00000370088	ENSP00000379383	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation	0.861
AMELX	KLK4	ENSP00000370088	ENSP00000326159	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	kallikrein-related peptidase 4; Involved in enamel formation	0.567
AMELX	MMP20	ENSP00000370088	ENSP00000260228	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation	0.724
AMELX	TUFT1	ENSP00000370088	ENSP00000357842	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	tuftelin 1; Involved in the mineralization and structural organization of enamel	0.747
AMTN	AMBN	ENSP00000341013	ENSP00000313809	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	0.860
AMTN	AMELX	ENSP00000341013	ENSP00000370088	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	0.758
AMTN	DSPP	ENSP00000341013	ENSP00000282478	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	dentin sialophosphoprotein; DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals	0.502

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