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STRINGSTRING
SLC6A18 SLC6A18 MRPL47 MRPL47 SPTAN1 SPTAN1 UQCRQ UQCRQ CLPTM1L CLPTM1L CHRNA3 CHRNA3 UBC UBC TERT TERT SLC6A3 SLC6A3 PIK3C3 PIK3C3 BICD1 BICD1
"CLPTM1L" - CLPTM1-like in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CLPTM1LCLPTM1-like; Enhances cisplatin-mediated apoptosis, when overexpressed (538 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.893
TERT
telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3’-chromosomal termini with the 6- n [...] (1132 aa)
            score_image   0.762
SLC6A18
solute carrier family 6, member 18; Functions as a sodium and chloride-dependent neutral amino acid transporter (By similarity) (628 aa)
            score_image   0.752
MRPL47
mitochondrial ribosomal protein L47 (250 aa)
        score_image       0.644
UQCRQ
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone (82 aa)
        score_image       0.644
SPTAN1
spectrin, alpha, non-erythrocytic 1 (2477 aa)
        score_image       0.644
PIK3C3
phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes (887 aa)
        score_image       0.613
SLC6A3
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (620 aa)
            score_image   0.598
BICD1
bicaudal D homolog 1 (Drosophila); Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex (975 aa)
            score_image   0.573
CHRNA3
cholinergic receptor, nicotinic, alpha 3 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (505 aa)
            score_image   0.568
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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