MKRN3 protein (Homo sapiens) - STRING network view

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MKRN3

makorin ring finger protein 3; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity) (507 aa)

Predicted Functional Partners:

MAGEL2

0.755

ATP10A

0.742

NDN

0.709

SNURF

0.706

UBE3A

0.656

GABRB3

0.636

GABRB2

0.626

SNRPN

0.609

OCA2

0.608

HERC2

0.602

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP10A	GABRB2	ENSP00000349325	ENSP00000274547	ATPase, class V, type 10A	gamma-aminobutyric acid (GABA) A receptor, beta 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.569
ATP10A	GABRB3	ENSP00000349325	ENSP00000299267	ATPase, class V, type 10A	gamma-aminobutyric acid (GABA) A receptor, beta 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.582
ATP10A	HERC2	ENSP00000349325	ENSP00000261609	ATPase, class V, type 10A	HECT and RLD domain containing E3 ubiquitin protein ligase 2	0.542
ATP10A	MAGEL2	ENSP00000349325	ENSP00000433433	ATPase, class V, type 10A	MAGE-like 2; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex	0.700
ATP10A	MKRN3	ENSP00000349325	ENSP00000313881	ATPase, class V, type 10A	makorin ring finger protein 3; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity)	0.742
ATP10A	NDN	ENSP00000349325	ENSP00000332643	ATPase, class V, type 10A	necdin homolog (mouse); Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity)	0.538
ATP10A	OCA2	ENSP00000349325	ENSP00000346659	ATPase, class V, type 10A	oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color	0.517
ATP10A	SNRPN	ENSP00000349325	ENSP00000306223	ATPase, class V, type 10A	small nuclear ribonucleoprotein polypeptide N; May be involved in tissue-specific alternative RNA processing events	0.608
ATP10A	SNURF	ENSP00000349325	ENSP00000336543	ATPase, class V, type 10A	SNRPN upstream reading frame	0.533
ATP10A	UBE3A	ENSP00000349325	ENSP00000381045	ATPase, class V, type 10A	ubiquitin protein ligase E3A	0.757
GABRB2	ATP10A	ENSP00000274547	ENSP00000349325	gamma-aminobutyric acid (GABA) A receptor, beta 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	ATPase, class V, type 10A	0.569
GABRB2	GABRB3	ENSP00000274547	ENSP00000299267	gamma-aminobutyric acid (GABA) A receptor, beta 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	gamma-aminobutyric acid (GABA) A receptor, beta 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.900
GABRB2	MAGEL2	ENSP00000274547	ENSP00000433433	gamma-aminobutyric acid (GABA) A receptor, beta 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	MAGE-like 2; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex	0.509
GABRB2	MKRN3	ENSP00000274547	ENSP00000313881	gamma-aminobutyric acid (GABA) A receptor, beta 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	makorin ring finger protein 3; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity)	0.626
GABRB2	NDN	ENSP00000274547	ENSP00000332643	gamma-aminobutyric acid (GABA) A receptor, beta 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	necdin homolog (mouse); Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity)	0.414
GABRB2	OCA2	ENSP00000274547	ENSP00000346659	gamma-aminobutyric acid (GABA) A receptor, beta 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color	0.502
GABRB2	SNURF	ENSP00000274547	ENSP00000336543	gamma-aminobutyric acid (GABA) A receptor, beta 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	SNRPN upstream reading frame	0.480
GABRB2	UBE3A	ENSP00000274547	ENSP00000381045	gamma-aminobutyric acid (GABA) A receptor, beta 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	ubiquitin protein ligase E3A	0.821
GABRB3	ATP10A	ENSP00000299267	ENSP00000349325	gamma-aminobutyric acid (GABA) A receptor, beta 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	ATPase, class V, type 10A	0.582
GABRB3	GABRB2	ENSP00000299267	ENSP00000274547	gamma-aminobutyric acid (GABA) A receptor, beta 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	gamma-aminobutyric acid (GABA) A receptor, beta 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.900

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