KIAA0195 protein (Homo sapiens) - STRING network view

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KIAA0195

KIAA0195 (1356 aa)

Predicted Functional Partners:

CDK5

0.892

DEPDC1B

0.704

KIAA0753

0.575

CDCA8

0.543

SHISA6

0.496

KIAA1609

0.489

UBC

0.483

DEPDC1

0.452

HMMR

0.448

KIAA1045

0.448

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDCA8	KIAA0195	ENSP00000316121	ENSP00000313885	cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment	KIAA0195	0.543
CDCA8	UBC	ENSP00000316121	ENSP00000344818	cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment	ubiquitin C	0.620
CDK5	KIAA0195	ENSP00000419782	ENSP00000313885	cyclin-dependent kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neurona [...]	KIAA0195	0.892
CDK5	UBC	ENSP00000419782	ENSP00000344818	cyclin-dependent kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neurona [...]	ubiquitin C	0.956
DEPDC1	KIAA0195	ENSP00000412292	ENSP00000313885	DEP domain containing 1; May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells	KIAA0195	0.452
DEPDC1	UBC	ENSP00000412292	ENSP00000344818	DEP domain containing 1; May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells	ubiquitin C	0.620
DEPDC1B	KIAA0195	ENSP00000265036	ENSP00000313885	DEP domain containing 1B	KIAA0195	0.704
HMMR	KIAA0195	ENSP00000377492	ENSP00000313885	hyaluronan-mediated motility receptor (RHAMM); Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity	KIAA0195	0.448
HMMR	UBC	ENSP00000377492	ENSP00000344818	hyaluronan-mediated motility receptor (RHAMM); Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity	ubiquitin C	0.483
KIAA0195	CDCA8	ENSP00000313885	ENSP00000316121	KIAA0195	cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment	0.543
KIAA0195	CDK5	ENSP00000313885	ENSP00000419782	KIAA0195	cyclin-dependent kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neurona [...]	0.892
KIAA0195	DEPDC1	ENSP00000313885	ENSP00000412292	KIAA0195	DEP domain containing 1; May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells	0.452
KIAA0195	DEPDC1B	ENSP00000313885	ENSP00000265036	KIAA0195	DEP domain containing 1B	0.704
KIAA0195	HMMR	ENSP00000313885	ENSP00000377492	KIAA0195	hyaluronan-mediated motility receptor (RHAMM); Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity	0.448
KIAA0195	KIAA0753	ENSP00000313885	ENSP00000355250	KIAA0195	KIAA0753	0.575
KIAA0195	KIAA1045	ENSP00000313885	ENSP00000242315	KIAA0195	KIAA1045	0.448
KIAA0195	KIAA1609	ENSP00000313885	ENSP00000343635	KIAA0195	KIAA1609	0.489
KIAA0195	SHISA6	ENSP00000313885	ENSP00000390084	KIAA0195	shisa homolog 6 (Xenopus laevis)	0.496
KIAA0195	UBC	ENSP00000313885	ENSP00000344818	KIAA0195	ubiquitin C	0.483
KIAA0753	KIAA0195	ENSP00000355250	ENSP00000313885	KIAA0753	KIAA0195	0.575

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