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TTYH3 TTYH3 BEST1 BEST1 BEST3 BEST3 CLCN1 CLCN1 BEST4 BEST4 ANO6 ANO6 BEST2 BEST2 CFTR CFTR ANO2 ANO2 CLIC6 CLIC6 TTYH2 TTYH2
"ANO2" - anoctamin 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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Score
ANO2anoctamin 2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina (998 aa)    
Predicted Functional Partners:
BEST2
bestrophin 2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate (509 aa)
          score_image score_image   0.793
BEST3
bestrophin 3; Forms calcium-sensitive (By similarity) chloride channels. Permeable to bicarbonate (By similarity) (668 aa)
          score_image score_image   0.753
BEST1
bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate (604 aa)
          score_image score_image   0.723
TTYH3
tweety homolog 3 (Drosophila); Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction (523 aa)
          score_image score_image   0.696
TTYH2
tweety homolog 2 (Drosophila); Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation (534 aa)
          score_image score_image   0.667
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
          score_image score_image   0.622
ANO6
anoctamin 6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (931 aa)
          score_image score_image score_image 0.590
CLCN1
chloride channel, voltage-sensitive 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport (988 aa)
          score_image score_image   0.586
BEST4
bestrophin 4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate (473 aa)
          score_image score_image   0.575
CLIC6
chloride intracellular channel 6; May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity) (686 aa)
          score_image score_image   0.575
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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