MBOAT4 protein (Homo sapiens) - STRING network view

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MBOAT4

membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid (435 aa)

Predicted Functional Partners:

PCSK1

0.915

SEC11C

0.900

SPCS3

0.900

SEC11A

0.900

SPCS2

0.900

SPCS1

0.900

SST

0.877

MTOR

0.829

GHSR

0.818

GHRL

0.816

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GHRL	GHSR	ENSP00000335074	ENSP00000241256	ghrelin/obestatin prepropeptide; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation	growth hormone secretagogue receptor; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine)	0.994
GHRL	MBOAT4	ENSP00000335074	ENSP00000314196	ghrelin/obestatin prepropeptide; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	0.816
GHRL	SST	ENSP00000335074	ENSP00000287641	ghrelin/obestatin prepropeptide; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation	somatostatin; Somatostatin inhibits the release of somatotropin	0.756
GHSR	GHRL	ENSP00000241256	ENSP00000335074	growth hormone secretagogue receptor; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine)	ghrelin/obestatin prepropeptide; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation	0.994
GHSR	MBOAT4	ENSP00000241256	ENSP00000314196	growth hormone secretagogue receptor; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine)	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	0.818
GHSR	SST	ENSP00000241256	ENSP00000287641	growth hormone secretagogue receptor; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine)	somatostatin; Somatostatin inhibits the release of somatotropin	0.725
MBOAT4	GHRL	ENSP00000314196	ENSP00000335074	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	ghrelin/obestatin prepropeptide; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation	0.816
MBOAT4	GHSR	ENSP00000314196	ENSP00000241256	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	growth hormone secretagogue receptor; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine)	0.818
MBOAT4	MTOR	ENSP00000314196	ENSP00000354558	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	mechanistic target of rapamycin (serine/threonine kinase); Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initi [...]	0.829
MBOAT4	PCSK1	ENSP00000314196	ENSP00000308024	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	proprotein convertase subtilisin/kexin type 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin	0.915
MBOAT4	SEC11A	ENSP00000314196	ENSP00000268220	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	SEC11 homolog A (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	0.900
MBOAT4	SEC11C	ENSP00000314196	ENSP00000468633	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	0.900
MBOAT4	SPCS1	ENSP00000314196	ENSP00000233025	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	signal peptidase complex subunit 1 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	0.900
MBOAT4	SPCS2	ENSP00000314196	ENSP00000263672	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	signal peptidase complex subunit 2 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	0.900
MBOAT4	SPCS3	ENSP00000314196	ENSP00000427463	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	signal peptidase complex subunit 3 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	0.900
MBOAT4	SST	ENSP00000314196	ENSP00000287641	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	somatostatin; Somatostatin inhibits the release of somatotropin	0.877
MTOR	MBOAT4	ENSP00000354558	ENSP00000314196	mechanistic target of rapamycin (serine/threonine kinase); Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initi [...]	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	0.829
MTOR	SST	ENSP00000354558	ENSP00000287641	mechanistic target of rapamycin (serine/threonine kinase); Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initi [...]	somatostatin; Somatostatin inhibits the release of somatotropin	0.508
PCSK1	MBOAT4	ENSP00000308024	ENSP00000314196	proprotein convertase subtilisin/kexin type 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin	membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid	0.915
PCSK1	SST	ENSP00000308024	ENSP00000287641	proprotein convertase subtilisin/kexin type 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin	somatostatin; Somatostatin inhibits the release of somatotropin	0.414

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