| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRIX1 | METTL1 | ENSP00000338862 | ENSP00000314441 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA | 0.836 |
| BRIX1 | NOP2 | ENSP00000338862 | ENSP00000382392 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.994 |
| BRIX1 | NSUN2 | ENSP00000338862 | ENSP00000264670 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | NOP2/Sun RNA methyltransferase family, member 2; RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Not able to modify tRNAs at positions 48 or 49. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity | 0.625 |
| BRIX1 | NSUN3 | ENSP00000338862 | ENSP00000318986 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | NOP2/Sun domain family, member 3; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | 0.625 |
| BRIX1 | NSUN4 | ENSP00000338862 | ENSP00000419740 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | NOP2/Sun domain family, member 4; Involved in mitochondrial ribosome large subunit biogenesis | 0.625 |
| BRIX1 | TRMT1 | ENSP00000338862 | ENSP00000350352 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups | 0.736 |
| BRIX1 | WDR4 | ENSP00000338862 | ENSP00000328671 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | WD repeat domain 4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit | 0.663 |
| DUS3L | EXOSC10 | ENSP00000311977 | ENSP00000366135 | dihydrouridine synthase 3-like (S. cerevisiae); Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) | exosome component 10; Putative catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] | 0.506 |
| DUS3L | METTL1 | ENSP00000311977 | ENSP00000314441 | dihydrouridine synthase 3-like (S. cerevisiae); Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) | methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA | 0.827 |
| DUS3L | NOP2 | ENSP00000311977 | ENSP00000382392 | dihydrouridine synthase 3-like (S. cerevisiae); Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.732 |
| DUS3L | NSUN2 | ENSP00000311977 | ENSP00000264670 | dihydrouridine synthase 3-like (S. cerevisiae); Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) | NOP2/Sun RNA methyltransferase family, member 2; RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Not able to modify tRNAs at positions 48 or 49. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity | 0.577 |
| DUS3L | TRMT1 | ENSP00000311977 | ENSP00000350352 | dihydrouridine synthase 3-like (S. cerevisiae); Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) | tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups | 0.607 |
| DUS3L | TRMT10A | ENSP00000311977 | ENSP00000273962 | dihydrouridine synthase 3-like (S. cerevisiae); Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) | tRNA methyltransferase 10 homolog A (S. cerevisiae); Probable RNA methyltransferase (By similarity) | 0.503 |
| DUS3L | WDR4 | ENSP00000311977 | ENSP00000328671 | dihydrouridine synthase 3-like (S. cerevisiae); Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) | WD repeat domain 4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit | 0.558 |
| EXOSC10 | DUS3L | ENSP00000366135 | ENSP00000311977 | exosome component 10; Putative catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] | dihydrouridine synthase 3-like (S. cerevisiae); Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) | 0.506 |
| EXOSC10 | METTL1 | ENSP00000366135 | ENSP00000314441 | exosome component 10; Putative catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] | methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA | 0.824 |
| EXOSC10 | NOP2 | ENSP00000366135 | ENSP00000382392 | exosome component 10; Putative catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.560 |
| EXOSC10 | NSUN2 | ENSP00000366135 | ENSP00000264670 | exosome component 10; Putative catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] | NOP2/Sun RNA methyltransferase family, member 2; RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Not able to modify tRNAs at positions 48 or 49. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity | 0.592 |
| EXOSC10 | NSUN3 | ENSP00000366135 | ENSP00000318986 | exosome component 10; Putative catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] | NOP2/Sun domain family, member 3; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | 0.450 |
| EXOSC10 | NSUN4 | ENSP00000366135 | ENSP00000419740 | exosome component 10; Putative catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] | NOP2/Sun domain family, member 4; Involved in mitochondrial ribosome large subunit biogenesis | 0.450 |
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