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FAU FAU HIP1R HIP1R HSPA8 HSPA8 CLHC1 CLHC1 GAK GAK CLTA CLTA UBC UBC CLTB CLTB CLTCL1 CLTCL1 CLTC CLTC VPS35 VPS35
"GAK" - cyclin G associated kinase in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
GAKcyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (1311 aa)    
Predicted Functional Partners:
CLTC
clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (1675 aa)
      score_image score_image   score_image   0.966
CLTB
clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (229 aa)
        score_image   score_image   0.955
CLTA
clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (248 aa)
        score_image   score_image   0.953
UBC
ubiquitin C (685 aa)
      score_image score_image   score_image   0.934
CLTCL1
clathrin, heavy chain-like 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity) (1640 aa)
      score_image score_image   score_image   0.920
CLHC1
clathrin heavy chain linker domain containing 1 (586 aa)
      score_image score_image   score_image   0.920
HSPA8
heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (646 aa)
        score_image   score_image   0.881
HIP1R
huntingtin interacting protein 1 related; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (1068 aa)
      score_image score_image   score_image   0.878
VPS35
vacuolar protein sorting 35 homolog (S. cerevisiae) (796 aa)
      score_image     score_image   0.863
FAU
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (133 aa)
      score_image score_image   score_image   0.850
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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