HYDIN protein (Homo sapiens) - STRING network view

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HYDIN

HYDIN, axonemal central pair apparatus protein (1017 aa)

Predicted Functional Partners:

NPEPPS

0.812

GPRIN2

0.811

UGT2B17

0.811

DRD5

0.760

SRGAP2

0.760

SRGAP3

0.759

GTF2I

0.754

INPP5B

0.733

CLUAP1

0.724

PCDP1

0.720

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLUAP1	HYDIN	ENSP00000460850	ENSP00000314736	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	HYDIN, axonemal central pair apparatus protein	0.724
DRD5	GPRIN2	ENSP00000306129	ENSP00000363433	dopamine receptor D5; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase	G protein regulated inducer of neurite outgrowth 2	0.759
DRD5	GTF2I	ENSP00000306129	ENSP00000322542	dopamine receptor D5; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase	general transcription factor IIi	0.749
DRD5	HYDIN	ENSP00000306129	ENSP00000314736	dopamine receptor D5; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase	HYDIN, axonemal central pair apparatus protein	0.760
DRD5	NPEPPS	ENSP00000306129	ENSP00000320324	dopamine receptor D5; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase	aminopeptidase puromycin sensitive; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain	0.759
DRD5	SRGAP2	ENSP00000306129	ENSP00000295713	dopamine receptor D5; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase	SLIT-ROBO Rho GTPase activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...]	0.757
DRD5	SRGAP3	ENSP00000306129	ENSP00000373347	dopamine receptor D5; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase	SLIT-ROBO Rho GTPase activating protein 3; GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons	0.755
DRD5	UGT2B17	ENSP00000306129	ENSP00000320401	dopamine receptor D5; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase	UDP glucuronosyltransferase 2 family, polypeptide B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT)	0.759
GPRIN2	DRD5	ENSP00000363433	ENSP00000306129	G protein regulated inducer of neurite outgrowth 2	dopamine receptor D5; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase	0.759
GPRIN2	GTF2I	ENSP00000363433	ENSP00000322542	G protein regulated inducer of neurite outgrowth 2	general transcription factor IIi	0.752
GPRIN2	HYDIN	ENSP00000363433	ENSP00000314736	G protein regulated inducer of neurite outgrowth 2	HYDIN, axonemal central pair apparatus protein	0.811
GPRIN2	NPEPPS	ENSP00000363433	ENSP00000320324	G protein regulated inducer of neurite outgrowth 2	aminopeptidase puromycin sensitive; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain	0.812
GPRIN2	SRGAP2	ENSP00000363433	ENSP00000295713	G protein regulated inducer of neurite outgrowth 2	SLIT-ROBO Rho GTPase activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...]	0.811
GPRIN2	SRGAP3	ENSP00000363433	ENSP00000373347	G protein regulated inducer of neurite outgrowth 2	SLIT-ROBO Rho GTPase activating protein 3; GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons	0.800
GPRIN2	UGT2B17	ENSP00000363433	ENSP00000320401	G protein regulated inducer of neurite outgrowth 2	UDP glucuronosyltransferase 2 family, polypeptide B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT)	0.812
GTF2I	DRD5	ENSP00000322542	ENSP00000306129	general transcription factor IIi	dopamine receptor D5; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase	0.749
GTF2I	GPRIN2	ENSP00000322542	ENSP00000363433	general transcription factor IIi	G protein regulated inducer of neurite outgrowth 2	0.752
GTF2I	HYDIN	ENSP00000322542	ENSP00000314736	general transcription factor IIi	HYDIN, axonemal central pair apparatus protein	0.754
GTF2I	NPEPPS	ENSP00000322542	ENSP00000320324	general transcription factor IIi	aminopeptidase puromycin sensitive; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain	0.752
GTF2I	SRGAP2	ENSP00000322542	ENSP00000295713	general transcription factor IIi	SLIT-ROBO Rho GTPase activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...]	0.749

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