Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | MBLAC2 | metallo-beta-lactamase domain containing 2 (279 aa) | ||||||||||||
Predicted Functional Partners:
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 | UBC | ubiquitin C (685 aa) |
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0.837 | |||||||||
 | MCEE | methylmalonyl CoA epimerase (176 aa) |
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0.560 | |||||||||
 | DTD2 | D-tyrosyl-tRNA deacylase 2 (putative); Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential) (168 aa) |
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0.559 | |||||||||
 | ENSG00000203546 | Uncharacterized protein (67 aa) |
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0.461 | ||||||||||
 | DTD1 | D-tyrosyl-tRNA deacylase 1; Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) (209 aa) |
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0.461 | ||||||||||
 | HDDC3 | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response (140 aa) |
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0.461 | ||||||||||
 | TXNRD1 | thioredoxin reductase 1 (649 aa) |
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0.459 | ||||||||||
 | TXNRD3 | thioredoxin reductase 3; Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity) (698 aa) |
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0.459 | ||||||||||
 | C8orf33 | chromosome 8 open reading frame 33 (229 aa) |
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0.441 | ||||||||||
 | FAHD2B | fumarylacetoacetate hydrolase domain containing 2B; May have hydrolase activity (By similarity) (314 aa) |
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0.438 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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