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DAZAP2 DAZAP2 CPEB1 CPEB1 DAZ1 DAZ1 ECD ECD BOLL BOLL CDC25A CDC25A NR1H3 NR1H3 CDC25C CDC25C NR1H2 NR1H2 CDC25B CDC25B STRA8 STRA8
"BOLL" - bol, boule-like in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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fusion edge
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textmining edge
textmining
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co-expression
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protein homology
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[Homology]
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BOLLbol, boule-like (Drosophila); Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation (By similarity) (295 aa)    
Predicted Functional Partners:
CDC25A
cell division cycle 25 homolog A (S. pombe); Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro (524 aa)
      score_image score_image   score_image   0.981
STRA8
stimulated by retinoic acid 8 homolog (mouse); Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase (By similarity) (330 aa)
            score_image   0.871
CDC25B
cell division cycle 25 homolog B (S. pombe) (580 aa)
      score_image score_image   score_image   0.852
DAZ1
deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells (744 aa)
        score_image   score_image score_image 0.852
CDC25C
cell division cycle 25 homolog C (S. pombe); Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity (473 aa)
      score_image score_image   score_image   0.815
CPEB1
cytoplasmic polyadenylation element binding protein 1; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5’-UUUUUAU- 3’) within the mRNA 3’-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation [...] (561 aa)
      score_image     score_image   0.795
DAZAP2
DAZ associated protein 2 (207 aa)
            score_image   0.758
ECD
ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes (677 aa)
            score_image   0.700
NR1H3
nuclear receptor subfamily 1, group H, member 3; Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) (447 aa)
            score_image   0.700
NR1H2
nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) (460 aa)
            score_image   0.700
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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