ALOXE3 protein (Homo sapiens) - STRING network view

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ALOXE3

arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known (843 aa)

Predicted Functional Partners:

NIPAL4

0.858

TGM1

0.857

ABHD5

0.757

HES7

0.745

ABCA12

0.704

LOX

0.684

CYP4F22

0.662

UBC

0.620

PLA2G4A

0.599

ALOX12B

0.596

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA12	ABHD5	ENSP00000272895	ENSP00000390849	ATP-binding cassette, sub-family A (ABC1), member 12; Probable transporter involved in lipid homeostasis	abhydrolase domain containing 5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation	0.516
ABCA12	ALOX12B	ENSP00000272895	ENSP00000315167	ATP-binding cassette, sub-family A (ABC1), member 12; Probable transporter involved in lipid homeostasis	arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE)	0.701
ABCA12	ALOXE3	ENSP00000272895	ENSP00000314879	ATP-binding cassette, sub-family A (ABC1), member 12; Probable transporter involved in lipid homeostasis	arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known	0.704
ABCA12	CYP4F22	ENSP00000272895	ENSP00000269703	ATP-binding cassette, sub-family A (ABC1), member 12; Probable transporter involved in lipid homeostasis	cytochrome P450, family 4, subfamily F, polypeptide 22	0.780
ABCA12	NIPAL4	ENSP00000272895	ENSP00000311687	ATP-binding cassette, sub-family A (ABC1), member 12; Probable transporter involved in lipid homeostasis	NIPA-like domain containing 4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway	0.861
ABCA12	TGM1	ENSP00000272895	ENSP00000206765	ATP-binding cassette, sub-family A (ABC1), member 12; Probable transporter involved in lipid homeostasis	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum	0.757
ABHD5	ABCA12	ENSP00000390849	ENSP00000272895	abhydrolase domain containing 5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation	ATP-binding cassette, sub-family A (ABC1), member 12; Probable transporter involved in lipid homeostasis	0.516
ABHD5	ALOX12B	ENSP00000390849	ENSP00000315167	abhydrolase domain containing 5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation	arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE)	0.758
ABHD5	ALOXE3	ENSP00000390849	ENSP00000314879	abhydrolase domain containing 5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation	arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known	0.757
ABHD5	NIPAL4	ENSP00000390849	ENSP00000311687	abhydrolase domain containing 5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation	NIPA-like domain containing 4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway	0.607
ABHD5	TGM1	ENSP00000390849	ENSP00000206765	abhydrolase domain containing 5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum	0.560
ABHD5	UBC	ENSP00000390849	ENSP00000344818	abhydrolase domain containing 5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation	ubiquitin C	0.515
ALOX12B	ABCA12	ENSP00000315167	ENSP00000272895	arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE)	ATP-binding cassette, sub-family A (ABC1), member 12; Probable transporter involved in lipid homeostasis	0.701
ALOX12B	ABHD5	ENSP00000315167	ENSP00000390849	arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE)	abhydrolase domain containing 5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation	0.758
ALOX12B	ALOXE3	ENSP00000315167	ENSP00000314879	arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE)	arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known	0.596
ALOX12B	CYP4F22	ENSP00000315167	ENSP00000269703	arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE)	cytochrome P450, family 4, subfamily F, polypeptide 22	0.661
ALOX12B	LOX	ENSP00000315167	ENSP00000231004	arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE)	lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression	0.695
ALOX12B	NIPAL4	ENSP00000315167	ENSP00000311687	arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE)	NIPA-like domain containing 4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway	0.857
ALOX12B	PLA2G4A	ENSP00000315167	ENSP00000356436	arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE)	phospholipase A2, group IVA (cytosolic, calcium-dependent); Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response	0.960
ALOX12B	TGM1	ENSP00000315167	ENSP00000206765	arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE)	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum	0.849

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