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STRINGSTRING
IL28B IL28B IL19 IL19 IL10 IL10 IL24 IL24 IL20RB IL20RB IL20 IL20 IL20RA IL20RA IL26 IL26 IL28A IL28A IL22 IL22 IL29 IL29
"IL20RA" - interleukin 20 receptor, alpha in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
IL20RAinterleukin 20 receptor, alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 (553 aa)    
Predicted Functional Partners:
IL20
interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 (176 aa)
        score_image score_image score_image   0.998
IL24
interleukin 24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation (207 aa)
        score_image score_image score_image   0.972
IL19
interleukin 19; May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity) (215 aa)
        score_image score_image score_image   0.965
IL20RB
interleukin 20 receptor beta; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24 (311 aa)
        score_image   score_image score_image 0.927
IL26
interleukin 26; May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin (171 aa)
          score_image score_image   0.923
IL28A
interleukin 28A (interferon, lambda 2); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...] (200 aa)
          score_image score_image   0.908
IL28B
interleukin 28B (interferon, lambda 3); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...] (196 aa)
          score_image score_image   0.895
IL29
interleukin 29 (interferon, lambda 1); Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway (200 aa)
          score_image score_image   0.882
IL10
interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells (178 aa)
          score_image score_image   0.866
IL22
interleukin 22; Cytokine that contributes to the inflammatory response in vivo (179 aa)
          score_image score_image   0.866
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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