node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL10 | IL19 | ENSP00000412237 | ENSP00000343000 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 19; May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity) | 0.899 |
IL10 | IL20 | ENSP00000412237 | ENSP00000356063 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 | 0.508 |
IL10 | IL20RA | ENSP00000412237 | ENSP00000314976 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 20 receptor, alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 | 0.866 |
IL10 | IL20RB | ENSP00000412237 | ENSP00000328133 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 20 receptor beta; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24 | 0.827 |
IL10 | IL22 | ENSP00000412237 | ENSP00000329384 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 22; Cytokine that contributes to the inflammatory response in vivo | 0.583 |
IL10 | IL24 | ENSP00000412237 | ENSP00000375795 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation | 0.469 |
IL10 | IL26 | ENSP00000412237 | ENSP00000229134 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 26; May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin | 0.457 |
IL10 | IL29 | ENSP00000412237 | ENSP00000329991 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 29 (interferon, lambda 1); Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway | 0.416 |
IL19 | IL10 | ENSP00000343000 | ENSP00000412237 | interleukin 19; May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity) | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | 0.899 |
IL19 | IL20RA | ENSP00000343000 | ENSP00000314976 | interleukin 19; May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity) | interleukin 20 receptor, alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 | 0.965 |
IL19 | IL20RB | ENSP00000343000 | ENSP00000328133 | interleukin 19; May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity) | interleukin 20 receptor beta; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24 | 0.938 |
IL19 | IL22 | ENSP00000343000 | ENSP00000329384 | interleukin 19; May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity) | interleukin 22; Cytokine that contributes to the inflammatory response in vivo | 0.576 |
IL19 | IL26 | ENSP00000343000 | ENSP00000229134 | interleukin 19; May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity) | interleukin 26; May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin | 0.565 |
IL19 | IL29 | ENSP00000343000 | ENSP00000329991 | interleukin 19; May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity) | interleukin 29 (interferon, lambda 1); Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway | 0.472 |
IL20 | IL10 | ENSP00000356063 | ENSP00000412237 | interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | 0.508 |
IL20 | IL20RA | ENSP00000356063 | ENSP00000314976 | interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 | interleukin 20 receptor, alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 | 0.998 |
IL20 | IL20RB | ENSP00000356063 | ENSP00000328133 | interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 | interleukin 20 receptor beta; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24 | 0.997 |
IL20 | IL22 | ENSP00000356063 | ENSP00000329384 | interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 | interleukin 22; Cytokine that contributes to the inflammatory response in vivo | 0.516 |
IL20 | IL26 | ENSP00000356063 | ENSP00000229134 | interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 | interleukin 26; May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin | 0.538 |
IL20 | IL29 | ENSP00000356063 | ENSP00000329991 | interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 | interleukin 29 (interferon, lambda 1); Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway | 0.416 |