EDNRA protein (Homo sapiens) - STRING network view

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Score

EDNRA

endothelin receptor type A (427 aa)

Predicted Functional Partners:

EDN1

0.999

EDN2

0.994

EDN3

0.994

MMP1

0.986

AGT

0.986

GNA11

0.963

KNG1

0.954

GNRH1

0.954

AVP

0.943

TAC1

0.942

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	AVP	ENSP00000355627	ENSP00000369647	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	0.949
AGT	EDN1	ENSP00000355627	ENSP00000368683	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides	0.968
AGT	EDN2	ENSP00000355627	ENSP00000361668	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides	0.912
AGT	EDN3	ENSP00000355627	ENSP00000337128	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	0.918
AGT	EDNRA	ENSP00000355627	ENSP00000315011	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	endothelin receptor type A	0.986
AGT	GNA11	ENSP00000355627	ENSP00000078429	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C	0.928
AGT	GNRH1	ENSP00000355627	ENSP00000276414	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones	0.906
AGT	KNG1	ENSP00000355627	ENSP00000265023	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...]	0.989
AGT	MMP1	ENSP00000355627	ENSP00000322788	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity	0.749
AGT	TAC1	ENSP00000355627	ENSP00000321106	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	tachykinin, precursor 1	0.930
AVP	AGT	ENSP00000369647	ENSP00000355627	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	0.949
AVP	EDN1	ENSP00000369647	ENSP00000368683	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides	0.993
AVP	EDN2	ENSP00000369647	ENSP00000361668	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides	0.917
AVP	EDN3	ENSP00000369647	ENSP00000337128	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	0.943
AVP	EDNRA	ENSP00000369647	ENSP00000315011	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	endothelin receptor type A	0.943
AVP	GNA11	ENSP00000369647	ENSP00000078429	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C	0.930
AVP	GNRH1	ENSP00000369647	ENSP00000276414	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones	0.938
AVP	KNG1	ENSP00000369647	ENSP00000265023	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...]	0.969
AVP	TAC1	ENSP00000369647	ENSP00000321106	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	tachykinin, precursor 1	0.960
EDN1	AGT	ENSP00000368683	ENSP00000355627	endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	0.968

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