KIAA1549L protein (Homo sapiens) - STRING network view

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KIAA1549L

KIAA1549-like (1849 aa)

Predicted Functional Partners:

CSTF3

0.863

DEPDC7

0.828

FBXO3

0.816

CD59

0.652

HIPK3

0.528

PLCL1

0.508

LMO2

0.497

CSTF1

0.493

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD59	CSTF3	ENSP00000340210	ENSP00000315791	CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase	cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs	0.519
CD59	KIAA1549L	ENSP00000340210	ENSP00000315295	CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase	KIAA1549-like	0.652
CSTF1	CSTF3	ENSP00000217109	ENSP00000315791	cleavage stimulation factor, 3’ pre-RNA, subunit 1, 50kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA	cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs	0.999
CSTF1	DEPDC7	ENSP00000217109	ENSP00000241051	cleavage stimulation factor, 3’ pre-RNA, subunit 1, 50kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA	DEP domain containing 7	0.493
CSTF1	KIAA1549L	ENSP00000217109	ENSP00000315295	cleavage stimulation factor, 3’ pre-RNA, subunit 1, 50kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA	KIAA1549-like	0.493
CSTF3	CD59	ENSP00000315791	ENSP00000340210	cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs	CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase	0.519
CSTF3	CSTF1	ENSP00000315791	ENSP00000217109	cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs	cleavage stimulation factor, 3’ pre-RNA, subunit 1, 50kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA	0.999
CSTF3	DEPDC7	ENSP00000315791	ENSP00000241051	cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs	DEP domain containing 7	0.863
CSTF3	KIAA1549L	ENSP00000315791	ENSP00000315295	cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs	KIAA1549-like	0.863
DEPDC7	CSTF1	ENSP00000241051	ENSP00000217109	DEP domain containing 7	cleavage stimulation factor, 3’ pre-RNA, subunit 1, 50kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA	0.493
DEPDC7	CSTF3	ENSP00000241051	ENSP00000315791	DEP domain containing 7	cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs	0.863
DEPDC7	KIAA1549L	ENSP00000241051	ENSP00000315295	DEP domain containing 7	KIAA1549-like	0.828
FBXO3	KIAA1549L	ENSP00000265651	ENSP00000315295	F-box protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53- dependent transactivation	KIAA1549-like	0.816
FBXO3	LMO2	ENSP00000265651	ENSP00000257818	F-box protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53- dependent transactivation	LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state	0.489
HIPK3	KIAA1549L	ENSP00000304226	ENSP00000315295	homeodomain interacting protein kinase 3; Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation- phosphoryla [...]	KIAA1549-like	0.528
KIAA1549L	CD59	ENSP00000315295	ENSP00000340210	KIAA1549-like	CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase	0.652
KIAA1549L	CSTF1	ENSP00000315295	ENSP00000217109	KIAA1549-like	cleavage stimulation factor, 3’ pre-RNA, subunit 1, 50kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA	0.493
KIAA1549L	CSTF3	ENSP00000315295	ENSP00000315791	KIAA1549-like	cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs	0.863
KIAA1549L	DEPDC7	ENSP00000315295	ENSP00000241051	KIAA1549-like	DEP domain containing 7	0.828
KIAA1549L	FBXO3	ENSP00000315295	ENSP00000265651	KIAA1549-like	F-box protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53- dependent transactivation	0.816

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