node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LSM2 | LSM3 | ENSP00000364813 | ENSP00000302160 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | 0.999 |
LSM2 | LSM4 | ENSP00000364813 | ENSP00000469468 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | 0.968 |
LSM2 | LSM6 | ENSP00000364813 | ENSP00000296581 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae); Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5’-to-3’ mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing [...] | 0.999 |
LSM2 | PRPF3 | ENSP00000364813 | ENSP00000315379 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) | 0.918 |
LSM2 | PRPF31 | ENSP00000364813 | ENSP00000324122 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | 0.657 |
LSM2 | PRPF4 | ENSP00000364813 | ENSP00000363313 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | PRP4 pre-mRNA processing factor 4 homolog (yeast); Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome | 0.970 |
LSM2 | PRPF6 | ENSP00000364813 | ENSP00000266079 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | 0.919 |
LSM2 | PRPF8 | ENSP00000364813 | ENSP00000304350 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.958 |
LSM2 | SNRPD1 | ENSP00000364813 | ENSP00000300413 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | small nuclear ribonucleoprotein D1 polypeptide 16kDa; May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA | 0.981 |
LSM2 | SNRPD3 | ENSP00000364813 | ENSP00000215829 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | small nuclear ribonucleoprotein D3 polypeptide 18kDa; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner | 0.986 |
LSM3 | LSM2 | ENSP00000302160 | ENSP00000364813 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.999 |
LSM3 | LSM4 | ENSP00000302160 | ENSP00000469468 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | 0.999 |
LSM3 | LSM6 | ENSP00000302160 | ENSP00000296581 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae); Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5’-to-3’ mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing [...] | 0.999 |
LSM3 | PRPF3 | ENSP00000302160 | ENSP00000315379 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) | 0.947 |
LSM3 | PRPF31 | ENSP00000302160 | ENSP00000324122 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | 0.649 |
LSM3 | PRPF4 | ENSP00000302160 | ENSP00000363313 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | PRP4 pre-mRNA processing factor 4 homolog (yeast); Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome | 0.954 |
LSM3 | PRPF6 | ENSP00000302160 | ENSP00000266079 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | 0.892 |
LSM3 | PRPF8 | ENSP00000302160 | ENSP00000304350 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.887 |
LSM3 | SNRPD1 | ENSP00000302160 | ENSP00000300413 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | small nuclear ribonucleoprotein D1 polypeptide 16kDa; May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA | 0.968 |
LSM3 | SNRPD3 | ENSP00000302160 | ENSP00000215829 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | small nuclear ribonucleoprotein D3 polypeptide 18kDa; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner | 0.999 |