SPEM1 protein (Homo sapiens) - STRING network view

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SPEM1

spermatid maturation 1; Required for proper cytoplasm removal during spermatogenesis (By similarity) (309 aa)

Predicted Functional Partners:

UBQLN1

0.865

DNAAF1

0.623

CNTROB

0.567

RSPH4A

0.567

CCDC39

0.566

AKAP3

0.563

RANBP17

0.561

GBA2

0.539

DPY19L2

0.515

TXNDC2

0.509

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP3	SPEM1	ENSP00000228850	ENSP00000315554	A kinase (PRKA) anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction	spermatid maturation 1; Required for proper cytoplasm removal during spermatogenesis (By similarity)	0.563
CCDC39	DNAAF1	ENSP00000405708	ENSP00000367815	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	dynein, axonemal, assembly factor 1; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli	0.585
CCDC39	DPY19L2	ENSP00000405708	ENSP00000315988	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	dpy-19-like 2 (C. elegans); Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation	0.402
CCDC39	RSPH4A	ENSP00000405708	ENSP00000229554	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	radial spoke head 4 homolog A (Chlamydomonas); Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules	0.755
CCDC39	SPEM1	ENSP00000405708	ENSP00000315554	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	spermatid maturation 1; Required for proper cytoplasm removal during spermatogenesis (By similarity)	0.566
CNTROB	SPEM1	ENSP00000369614	ENSP00000315554	centrobin, centrosomal BRCA2 interacting protein; Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis	spermatid maturation 1; Required for proper cytoplasm removal during spermatogenesis (By similarity)	0.567
DNAAF1	CCDC39	ENSP00000367815	ENSP00000405708	dynein, axonemal, assembly factor 1; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	0.585
DNAAF1	RSPH4A	ENSP00000367815	ENSP00000229554	dynein, axonemal, assembly factor 1; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli	radial spoke head 4 homolog A (Chlamydomonas); Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules	0.693
DNAAF1	SPEM1	ENSP00000367815	ENSP00000315554	dynein, axonemal, assembly factor 1; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli	spermatid maturation 1; Required for proper cytoplasm removal during spermatogenesis (By similarity)	0.623
DPY19L2	CCDC39	ENSP00000315988	ENSP00000405708	dpy-19-like 2 (C. elegans); Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	0.402
DPY19L2	GBA2	ENSP00000315988	ENSP00000367343	dpy-19-like 2 (C. elegans); Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation	glucosidase, beta (bile acid) 2; Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo	0.804
DPY19L2	SPEM1	ENSP00000315988	ENSP00000315554	dpy-19-like 2 (C. elegans); Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation	spermatid maturation 1; Required for proper cytoplasm removal during spermatogenesis (By similarity)	0.515
GBA2	DPY19L2	ENSP00000367343	ENSP00000315988	glucosidase, beta (bile acid) 2; Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo	dpy-19-like 2 (C. elegans); Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation	0.804
GBA2	SPEM1	ENSP00000367343	ENSP00000315554	glucosidase, beta (bile acid) 2; Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo	spermatid maturation 1; Required for proper cytoplasm removal during spermatogenesis (By similarity)	0.539
RANBP17	SPEM1	ENSP00000427975	ENSP00000315554	RAN binding protein 17; May function as a nuclear transport receptor (By similarity)	spermatid maturation 1; Required for proper cytoplasm removal during spermatogenesis (By similarity)	0.561
RSPH4A	CCDC39	ENSP00000229554	ENSP00000405708	radial spoke head 4 homolog A (Chlamydomonas); Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	0.755
RSPH4A	DNAAF1	ENSP00000229554	ENSP00000367815	radial spoke head 4 homolog A (Chlamydomonas); Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules	dynein, axonemal, assembly factor 1; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli	0.693
RSPH4A	SPEM1	ENSP00000229554	ENSP00000315554	radial spoke head 4 homolog A (Chlamydomonas); Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules	spermatid maturation 1; Required for proper cytoplasm removal during spermatogenesis (By similarity)	0.567
SPEM1	AKAP3	ENSP00000315554	ENSP00000228850	spermatid maturation 1; Required for proper cytoplasm removal during spermatogenesis (By similarity)	A kinase (PRKA) anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction	0.563
SPEM1	CCDC39	ENSP00000315554	ENSP00000405708	spermatid maturation 1; Required for proper cytoplasm removal during spermatogenesis (By similarity)	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	0.566

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