PEX7 protein (Homo sapiens) - STRING network view

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PEX7

peroxisomal biogenesis factor 7; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import (323 aa)

Predicted Functional Partners:

PEX5

0.999

PEX13

0.999

PEX14

0.995

ACAA1

0.968

PEX5L

0.940

PHYH

0.917

PEX12

0.763

PEX6

0.763

ACAT1

0.750

H326

0.714

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	ACAT1	ENSP00000333664	ENSP00000265838	acetyl-CoA acyltransferase 1	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	0.924
ACAA1	PEX14	ENSP00000333664	ENSP00000349016	acetyl-CoA acyltransferase 1	peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17	0.481
ACAA1	PEX5	ENSP00000333664	ENSP00000407401	acetyl-CoA acyltransferase 1	peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import	0.642
ACAA1	PEX5L	ENSP00000333664	ENSP00000419975	acetyl-CoA acyltransferase 1	peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity)	0.521
ACAA1	PEX7	ENSP00000333664	ENSP00000315680	acetyl-CoA acyltransferase 1	peroxisomal biogenesis factor 7; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import	0.968
ACAT1	ACAA1	ENSP00000265838	ENSP00000333664	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	acetyl-CoA acyltransferase 1	0.924
ACAT1	PEX7	ENSP00000265838	ENSP00000315680	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	peroxisomal biogenesis factor 7; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import	0.750
H326	PEX12	ENSP00000451235	ENSP00000225873	DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	0.978
H326	PEX13	ENSP00000451235	ENSP00000295030	DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex	peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins	0.978
H326	PEX14	ENSP00000451235	ENSP00000349016	DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex	peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17	0.975
H326	PEX5	ENSP00000451235	ENSP00000407401	DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex	peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import	0.844
H326	PEX5L	ENSP00000451235	ENSP00000419975	DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex	peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity)	0.686
H326	PEX6	ENSP00000451235	ENSP00000303511	DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex	peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	0.945
H326	PEX7	ENSP00000451235	ENSP00000315680	DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex	peroxisomal biogenesis factor 7; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import	0.714
PEX12	H326	ENSP00000225873	ENSP00000451235	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex	0.978
PEX12	PEX13	ENSP00000225873	ENSP00000295030	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins	0.994
PEX12	PEX14	ENSP00000225873	ENSP00000349016	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17	0.988
PEX12	PEX5	ENSP00000225873	ENSP00000407401	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import	0.999
PEX12	PEX5L	ENSP00000225873	ENSP00000419975	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity)	0.949
PEX12	PEX6	ENSP00000225873	ENSP00000303511	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	0.877

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