| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AHCYL2 | BHMT | ENSP00000315931 | ENSP00000274353 | adenosylhomocysteinase-like 2 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | 0.946 |
| AHCYL2 | CBS | ENSP00000315931 | ENSP00000344460 | adenosylhomocysteinase-like 2 | cystathionine-beta-synthase; Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity) | 0.940 |
| AHCYL2 | CTH | ENSP00000315931 | ENSP00000359976 | adenosylhomocysteinase-like 2 | cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...] | 0.888 |
| AHCYL2 | DNMT1 | ENSP00000315931 | ENSP00000352516 | adenosylhomocysteinase-like 2 | DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...] | 0.911 |
| AHCYL2 | DNMT3A | ENSP00000315931 | ENSP00000264709 | adenosylhomocysteinase-like 2 | DNA (cytosine-5-)-methyltransferase 3 alpha; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Can actively [...] | 0.909 |
| AHCYL2 | DNMT3B | ENSP00000315931 | ENSP00000328547 | adenosylhomocysteinase-like 2 | DNA (cytosine-5-)-methyltransferase 3 beta | 0.908 |
| AHCYL2 | MAT1A | ENSP00000315931 | ENSP00000361280 | adenosylhomocysteinase-like 2 | methionine adenosyltransferase I, alpha; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity) | 0.928 |
| AHCYL2 | MAT2A | ENSP00000315931 | ENSP00000303147 | adenosylhomocysteinase-like 2 | methionine adenosyltransferase II, alpha; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity) | 0.929 |
| AHCYL2 | MTR | ENSP00000315931 | ENSP00000355536 | adenosylhomocysteinase-like 2 | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.962 |
| AHCYL2 | UBC | ENSP00000315931 | ENSP00000344818 | adenosylhomocysteinase-like 2 | ubiquitin C | 0.866 |
| BHMT | AHCYL2 | ENSP00000274353 | ENSP00000315931 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | adenosylhomocysteinase-like 2 | 0.946 |
| BHMT | CBS | ENSP00000274353 | ENSP00000344460 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | cystathionine-beta-synthase; Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity) | 0.981 |
| BHMT | CTH | ENSP00000274353 | ENSP00000359976 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...] | 0.948 |
| BHMT | DNMT1 | ENSP00000274353 | ENSP00000352516 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...] | 0.416 |
| BHMT | MAT1A | ENSP00000274353 | ENSP00000361280 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | methionine adenosyltransferase I, alpha; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity) | 0.967 |
| BHMT | MAT2A | ENSP00000274353 | ENSP00000303147 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | methionine adenosyltransferase II, alpha; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity) | 0.963 |
| BHMT | MTR | ENSP00000274353 | ENSP00000355536 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.611 |
| CBS | AHCYL2 | ENSP00000344460 | ENSP00000315931 | cystathionine-beta-synthase; Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity) | adenosylhomocysteinase-like 2 | 0.940 |
| CBS | BHMT | ENSP00000344460 | ENSP00000274353 | cystathionine-beta-synthase; Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity) | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | 0.981 |
| CBS | CTH | ENSP00000344460 | ENSP00000359976 | cystathionine-beta-synthase; Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity) | cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...] | 0.997 |
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