node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF12 | CLEC4M | ENSP00000380942 | ENSP00000316228 | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | C-type lectin domain family 4, member M | 0.800 |
ARHGEF12 | RHOA | ENSP00000380942 | ENSP00000400175 | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.999 |
C1QA | CLEC4M | ENSP00000363773 | ENSP00000316228 | complement component 1, q subcomponent, A chain; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes | C-type lectin domain family 4, member M | 0.728 |
CLEC4M | ARHGEF12 | ENSP00000316228 | ENSP00000380942 | C-type lectin domain family 4, member M | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.800 |
CLEC4M | C1QA | ENSP00000316228 | ENSP00000363773 | C-type lectin domain family 4, member M | complement component 1, q subcomponent, A chain; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes | 0.728 |
CLEC4M | FURIN | ENSP00000316228 | ENSP00000268171 | C-type lectin domain family 4, member M | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | 0.877 |
CLEC4M | FUT4 | ENSP00000316228 | ENSP00000351602 | C-type lectin domain family 4, member M | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific); May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens | 0.815 |
CLEC4M | ICAM3 | ENSP00000316228 | ENSP00000160262 | C-type lectin domain family 4, member M | intercellular adhesion molecule 3; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2 | 0.900 |
CLEC4M | ITIH4 | ENSP00000316228 | ENSP00000266041 | C-type lectin domain family 4, member M | inter-alpha-trypsin inhibitor heavy chain family, member 4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration | 0.926 |
CLEC4M | KSR1 | ENSP00000316228 | ENSP00000323178 | C-type lectin domain family 4, member M | kinase suppressor of ras 1; Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity | 0.800 |
CLEC4M | LSP1 | ENSP00000316228 | ENSP00000308383 | C-type lectin domain family 4, member M | lymphocyte-specific protein 1 | 0.933 |
CLEC4M | PLK3 | ENSP00000316228 | ENSP00000361275 | C-type lectin domain family 4, member M | polo-like kinase 3; Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation- required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key rol [...] | 0.800 |
CLEC4M | RHOA | ENSP00000316228 | ENSP00000400175 | C-type lectin domain family 4, member M | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.800 |
FURIN | CLEC4M | ENSP00000268171 | ENSP00000316228 | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | C-type lectin domain family 4, member M | 0.877 |
FURIN | ITIH4 | ENSP00000268171 | ENSP00000266041 | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | inter-alpha-trypsin inhibitor heavy chain family, member 4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration | 0.580 |
FURIN | RHOA | ENSP00000268171 | ENSP00000400175 | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.442 |
FUT4 | CLEC4M | ENSP00000351602 | ENSP00000316228 | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific); May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens | C-type lectin domain family 4, member M | 0.815 |
ICAM3 | CLEC4M | ENSP00000160262 | ENSP00000316228 | intercellular adhesion molecule 3; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2 | C-type lectin domain family 4, member M | 0.900 |
ICAM3 | ITIH4 | ENSP00000160262 | ENSP00000266041 | intercellular adhesion molecule 3; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2 | inter-alpha-trypsin inhibitor heavy chain family, member 4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration | 0.585 |
ITIH4 | CLEC4M | ENSP00000266041 | ENSP00000316228 | inter-alpha-trypsin inhibitor heavy chain family, member 4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration | C-type lectin domain family 4, member M | 0.926 |