CCDC102B protein (Homo sapiens) - STRING network view

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CCDC102B

coiled-coil domain containing 102B (513 aa)

Predicted Functional Partners:

MARK1

0.692

TMX3

0.650

DOK6

0.563

CDH19

0.502

GFER

0.461

CCDC71L

0.450

PTCHD4

0.450

KRTAP1-5

0.418

CHST9

0.416

ARL4D

0.414

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL4D	CCDC102B	ENSP00000322628	ENSP00000316237	ADP-ribosylation factor-like 4D; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form	coiled-coil domain containing 102B	0.414
CCDC102B	ARL4D	ENSP00000316237	ENSP00000322628	coiled-coil domain containing 102B	ADP-ribosylation factor-like 4D; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form	0.414
CCDC102B	CCDC71L	ENSP00000316237	ENSP00000430897	coiled-coil domain containing 102B	coiled-coil domain containing 71-like	0.450
CCDC102B	CDH19	ENSP00000316237	ENSP00000262150	coiled-coil domain containing 102B	cadherin 19, type 2; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types	0.502
CCDC102B	CHST9	ENSP00000316237	ENSP00000284224	coiled-coil domain containing 102B	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin	0.416
CCDC102B	DOK6	ENSP00000316237	ENSP00000372160	coiled-coil domain containing 102B	docking protein 6; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret- mediated neurite growth. May have a role in brain development and/or maintenance	0.563
CCDC102B	GFER	ENSP00000316237	ENSP00000248114	coiled-coil domain containing 102B	growth factor, augmenter of liver regeneration; Isoform 1- FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen	0.461
CCDC102B	KRTAP1-5	ENSP00000316237	ENSP00000355302	coiled-coil domain containing 102B	keratin associated protein 1-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins	0.418
CCDC102B	MARK1	ENSP00000316237	ENSP00000355884	coiled-coil domain containing 102B	MAP/microtubule affinity-regulating kinase 1; Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the [...]	0.692
CCDC102B	PTCHD4	ENSP00000316237	ENSP00000341914	coiled-coil domain containing 102B	patched domain containing 4	0.450
CCDC102B	TMX3	ENSP00000316237	ENSP00000299608	coiled-coil domain containing 102B	thioredoxin-related transmembrane protein 3; Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase	0.650
CCDC71L	CCDC102B	ENSP00000430897	ENSP00000316237	coiled-coil domain containing 71-like	coiled-coil domain containing 102B	0.450
CCDC71L	KRTAP1-5	ENSP00000430897	ENSP00000355302	coiled-coil domain containing 71-like	keratin associated protein 1-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins	0.414
CCDC71L	PTCHD4	ENSP00000430897	ENSP00000341914	coiled-coil domain containing 71-like	patched domain containing 4	0.416
CDH19	CCDC102B	ENSP00000262150	ENSP00000316237	cadherin 19, type 2; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types	coiled-coil domain containing 102B	0.502
CHST9	CCDC102B	ENSP00000284224	ENSP00000316237	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin	coiled-coil domain containing 102B	0.416
CHST9	DOK6	ENSP00000284224	ENSP00000372160	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin	docking protein 6; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret- mediated neurite growth. May have a role in brain development and/or maintenance	0.481
DOK6	CCDC102B	ENSP00000372160	ENSP00000316237	docking protein 6; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret- mediated neurite growth. May have a role in brain development and/or maintenance	coiled-coil domain containing 102B	0.563
DOK6	CHST9	ENSP00000372160	ENSP00000284224	docking protein 6; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret- mediated neurite growth. May have a role in brain development and/or maintenance	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin	0.481
DOK6	TMX3	ENSP00000372160	ENSP00000299608	docking protein 6; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret- mediated neurite growth. May have a role in brain development and/or maintenance	thioredoxin-related transmembrane protein 3; Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase	0.581

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