| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGTR1 | DNAJC14 | ENSP00000273430 | ENSP00000316240 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | 0.585 |
| CANX | DNAJC14 | ENSP00000247461 | ENSP00000316240 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | 0.669 |
| CANX | HSPA5 | ENSP00000247461 | ENSP00000324173 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.937 |
| CHRM2 | DNAJC14 | ENSP00000319984 | ENSP00000316240 | cholinergic receptor, muscarinic 2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | 0.651 |
| CNTROB | DNAJC14 | ENSP00000369614 | ENSP00000316240 | centrobin, centrosomal BRCA2 interacting protein; Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | 0.532 |
| DDX3X | DNAJC14 | ENSP00000382840 | ENSP00000316240 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded DNA with a preference for 5’- single stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can [...] | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | 0.615 |
| DNAJC14 | AGTR1 | ENSP00000316240 | ENSP00000273430 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.585 |
| DNAJC14 | CANX | ENSP00000316240 | ENSP00000247461 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | 0.669 |
| DNAJC14 | CHRM2 | ENSP00000316240 | ENSP00000319984 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | cholinergic receptor, muscarinic 2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition | 0.651 |
| DNAJC14 | CNTROB | ENSP00000316240 | ENSP00000369614 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | centrobin, centrosomal BRCA2 interacting protein; Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis | 0.532 |
| DNAJC14 | DDX3X | ENSP00000316240 | ENSP00000382840 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded DNA with a preference for 5’- single stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can [...] | 0.615 |
| DNAJC14 | DRD1 | ENSP00000316240 | ENSP00000327652 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | dopamine receptor D1; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase | 0.937 |
| DNAJC14 | HSPA5 | ENSP00000316240 | ENSP00000324173 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.609 |
| DNAJC14 | PPP1R1B | ENSP00000316240 | ENSP00000254079 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | protein phosphatase 1, regulatory (inhibitor) subunit 1B; Inhibitor of protein-phosphatase 1 | 0.516 |
| DNAJC14 | PRPF31 | ENSP00000316240 | ENSP00000324122 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | 0.536 |
| DNAJC14 | ZNF48 | ENSP00000316240 | ENSP00000324056 | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | zinc finger protein 48; May be involved in transcriptional regulation | 0.675 |
| DRD1 | DNAJC14 | ENSP00000327652 | ENSP00000316240 | dopamine receptor D1; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | 0.937 |
| DRD1 | PPP1R1B | ENSP00000327652 | ENSP00000254079 | dopamine receptor D1; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase | protein phosphatase 1, regulatory (inhibitor) subunit 1B; Inhibitor of protein-phosphatase 1 | 0.516 |
| HSPA5 | CANX | ENSP00000324173 | ENSP00000247461 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | 0.937 |
| HSPA5 | DNAJC14 | ENSP00000324173 | ENSP00000316240 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) | 0.609 |
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