node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARSD | DHRSX | ENSP00000370546 | ENSP00000334113 | arylsulfatase D | dehydrogenase/reductase (SDR family) X-linked | 0.506 |
ARSD | GTPBP6 | ENSP00000370546 | ENSP00000316598 | arylsulfatase D | GTP binding protein 6 (putative) | 0.576 |
ARSD | PLCXD1 | ENSP00000370546 | ENSP00000371073 | arylsulfatase D | phosphatidylinositol-specific phospholipase C, X domain containing 1 | 0.440 |
ARSD | PPP2R3B | ENSP00000370546 | ENSP00000375080 | arylsulfatase D | protein phosphatase 2, regulatory subunit B’’, beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | 0.462 |
ASMT | DHRSX | ENSP00000370639 | ENSP00000334113 | acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity | dehydrogenase/reductase (SDR family) X-linked | 0.459 |
ASMT | GTPBP6 | ENSP00000370639 | ENSP00000316598 | acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity | GTP binding protein 6 (putative) | 0.590 |
ASMT | TBL1Y | ENSP00000370639 | ENSP00000328879 | acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity | transducin (beta)-like 1, Y-linked; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity) | 0.506 |
ASMTL | DHRSX | ENSP00000370718 | ENSP00000334113 | acetylserotonin O-methyltransferase-like; Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity | dehydrogenase/reductase (SDR family) X-linked | 0.548 |
ASMTL | GTPBP6 | ENSP00000370718 | ENSP00000316598 | acetylserotonin O-methyltransferase-like; Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity | GTP binding protein 6 (putative) | 0.686 |
ASMTL | PPP2R3B | ENSP00000370718 | ENSP00000375080 | acetylserotonin O-methyltransferase-like; Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity | protein phosphatase 2, regulatory subunit B’’, beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | 0.471 |
ASMTL | TBL1Y | ENSP00000370718 | ENSP00000328879 | acetylserotonin O-methyltransferase-like; Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity | transducin (beta)-like 1, Y-linked; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity) | 0.655 |
DHRSX | ARSD | ENSP00000334113 | ENSP00000370546 | dehydrogenase/reductase (SDR family) X-linked | arylsulfatase D | 0.506 |
DHRSX | ASMT | ENSP00000334113 | ENSP00000370639 | dehydrogenase/reductase (SDR family) X-linked | acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity | 0.459 |
DHRSX | ASMTL | ENSP00000334113 | ENSP00000370718 | dehydrogenase/reductase (SDR family) X-linked | acetylserotonin O-methyltransferase-like; Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity | 0.548 |
DHRSX | GTPBP6 | ENSP00000334113 | ENSP00000316598 | dehydrogenase/reductase (SDR family) X-linked | GTP binding protein 6 (putative) | 0.746 |
DHRSX | PLCXD1 | ENSP00000334113 | ENSP00000371073 | dehydrogenase/reductase (SDR family) X-linked | phosphatidylinositol-specific phospholipase C, X domain containing 1 | 0.484 |
GTPBP4 | GTPBP6 | ENSP00000354040 | ENSP00000316598 | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | GTP binding protein 6 (putative) | 0.759 |
GTPBP6 | ARSD | ENSP00000316598 | ENSP00000370546 | GTP binding protein 6 (putative) | arylsulfatase D | 0.576 |
GTPBP6 | ASMT | ENSP00000316598 | ENSP00000370639 | GTP binding protein 6 (putative) | acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity | 0.590 |
GTPBP6 | ASMTL | ENSP00000316598 | ENSP00000370718 | GTP binding protein 6 (putative) | acetylserotonin O-methyltransferase-like; Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity | 0.686 |