node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD1 | OSBPL2 | ENSP00000326491 | ENSP00000316649 | abhydrolase domain containing 1 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | 0.597 |
ABHD3 | OSBPL2 | ENSP00000289119 | ENSP00000316649 | abhydrolase domain containing 3 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | 0.587 |
ABHD3 | UBC | ENSP00000289119 | ENSP00000344818 | abhydrolase domain containing 3 | ubiquitin C | 0.746 |
MOSPD3 | OSBPL2 | ENSP00000223054 | ENSP00000316649 | motile sperm domain containing 3 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | 0.602 |
OSBPL2 | ABHD1 | ENSP00000316649 | ENSP00000326491 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | abhydrolase domain containing 1 | 0.597 |
OSBPL2 | ABHD3 | ENSP00000316649 | ENSP00000289119 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | abhydrolase domain containing 3 | 0.587 |
OSBPL2 | MOSPD3 | ENSP00000316649 | ENSP00000223054 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | motile sperm domain containing 3 | 0.602 |
OSBPL2 | PRKD1 | ENSP00000316649 | ENSP00000333568 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphoryl [...] | 0.613 |
OSBPL2 | PRKD2 | ENSP00000316649 | ENSP00000291281 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombes [...] | 0.613 |
OSBPL2 | PRKD3 | ENSP00000316649 | ENSP00000234179 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity) | 0.613 |
OSBPL2 | RAB7A | ENSP00000316649 | ENSP00000265062 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | 0.723 |
OSBPL2 | UBC | ENSP00000316649 | ENSP00000344818 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | ubiquitin C | 0.795 |
OSBPL2 | VAPA | ENSP00000316649 | ENSP00000345656 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking | 0.695 |
OSBPL2 | VAPB | ENSP00000316649 | ENSP00000417175 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | VAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation | 0.922 |
PRKD1 | OSBPL2 | ENSP00000333568 | ENSP00000316649 | protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphoryl [...] | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | 0.613 |
PRKD1 | UBC | ENSP00000333568 | ENSP00000344818 | protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphoryl [...] | ubiquitin C | 0.534 |
PRKD2 | OSBPL2 | ENSP00000291281 | ENSP00000316649 | protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombes [...] | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | 0.613 |
PRKD2 | UBC | ENSP00000291281 | ENSP00000344818 | protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombes [...] | ubiquitin C | 0.518 |
PRKD3 | OSBPL2 | ENSP00000234179 | ENSP00000316649 | protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity) | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | 0.613 |
PRKD3 | UBC | ENSP00000234179 | ENSP00000344818 | protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity) | ubiquitin C | 0.518 |