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STRINGSTRING
CCDC18 CCDC18 CCDC104 CCDC104 KIAA1731 KIAA1731 C10orf90 C10orf90 SPICE1 SPICE1 CEP120 CEP120 CEP135 CEP135 UBC UBC TRIM36 TRIM36
KIAA1731 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KIAA1731KIAA1731; May be involved in centriole formation or stability (2601 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
         score_image       0.730
CCDC18
coiled-coil domain containing 18 (1508 aa)
             score_image   0.679
SPICE1
spindle and centriole associated protein 1; Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis (855 aa)
             score_image   0.666
CCDC104
coiled-coil domain containing 104; May act as an effector for ARL3 (342 aa)
             score_image   0.612
CEP120
centrosomal protein 120kDa; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity) (986 aa)
             score_image   0.549
CEP135
centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole (1140 aa)
             score_image   0.480
TRIM36
tripartite motif containing 36; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization (By similarity) (728 aa)
             score_image   0.473
C10orf90
chromosome 10 open reading frame 90; Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity). May have a role in the assembly of primary cilia (699 aa)
             score_image   0.471
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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