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NOVA1 NOVA1 SRSF6 SRSF6 SRSF4 SRSF4 CDK13 CDK13 COG8 COG8 MYEF2 MYEF2 CDK12 CDK12 CDK9 CDK9 NOVA2 NOVA2 THOC2 THOC2 SMARCA4 SMARCA4
"MYEF2" - myelin expression factor 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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experimentally determined
Predicted Interactions
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gene co-occurrence
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Score
MYEF2myelin expression factor 2 (600 aa)    
Predicted Functional Partners:
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephos [...] (1679 aa)
      score_image score_image       0.833
CDK12
cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors (1490 aa)
      score_image score_image   score_image   0.800
CDK9
cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytok [...] (372 aa)
      score_image score_image   score_image   0.800
CDK13
cyclin-dependent kinase 13 (1512 aa)
      score_image score_image   score_image   0.800
THOC2
THO complex 2; Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex [...] (1593 aa)
        score_image   score_image   0.765
NOVA1
neuro-oncological ventral antigen 1; May regulate RNA splicing or metabolism in a specific subset of developing neurons (507 aa)
        score_image   score_image   0.753
NOVA2
neuro-oncological ventral antigen 2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA (492 aa)
        score_image   score_image   0.753
COG8
component of oligomeric golgi complex 8; Required for normal Golgi function (By similarity) (612 aa)
        score_image       0.736
SRSF4
serine/arginine-rich splicing factor 4; Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 (494 aa)
      score_image score_image   score_image   0.723
SRSF6
serine/arginine-rich splicing factor 6; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 (344 aa)
      score_image score_image   score_image   0.723
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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