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OPRM1 OPRM1 CCR5 CCR5 CXCR4 CXCR4 CCR4 CCR4 MYO18B MYO18B ADRBK2 ADRBK2 ARRB1 ARRB1 ARRB2 ARRB2 SEZ6L SEZ6L F2R F2R TBXA2R TBXA2R
"ADRBK2" - adrenergic, beta, receptor kinase 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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experimentally determined
Predicted Interactions
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textmining
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protein homology
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[Homology]
Score
ADRBK2adrenergic, beta, receptor kinase 2; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors (688 aa)    
Predicted Functional Partners:
ARRB2
arrestin, beta 2 (409 aa)
          score_image score_image   0.957
ARRB1
arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] (418 aa)
          score_image score_image   0.956
OPRM1
opioid receptor, mu 1 (493 aa)
        score_image score_image score_image   0.918
CXCR4
chemokine (C-X-C motif) receptor 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar develo [...] (356 aa)
        score_image score_image score_image   0.915
CCR4
chemokine (C-C motif) receptor 4; High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival (360 aa)
        score_image score_image score_image   0.915
CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene) (352 aa)
        score_image score_image score_image   0.915
TBXA2R
thromboxane A2 receptor; Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase (407 aa)
          score_image score_image   0.904
F2R
coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development (425 aa)
          score_image     0.900
SEZ6L
seizure related 6 homolog (mouse)-like (1024 aa)
            score_image   0.885
MYO18B
myosin XVIIIB (2567 aa)
            score_image   0.882
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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