node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARID4B | UBC | ENSP00000264183 | ENSP00000344818 | AT rich interactive domain 4B (RBP1-like) | ubiquitin C | 0.541 |
ARID4B | UTY | ENSP00000264183 | ENSP00000328939 | AT rich interactive domain 4B (RBP1-like) | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) | 0.659 |
ARID4B | ZNF322 | ENSP00000264183 | ENSP00000418897 | AT rich interactive domain 4B (RBP1-like) | zinc finger protein 322; Involved in transcriptional regulation as an activator | 0.445 |
ARID4B | ZNF518B | ENSP00000264183 | ENSP00000317614 | AT rich interactive domain 4B (RBP1-like) | zinc finger protein 518B; May be involved in transcriptional regulation | 0.479 |
FBXL19 | UTY | ENSP00000369666 | ENSP00000328939 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) | 0.615 |
FBXL19 | ZNF322 | ENSP00000369666 | ENSP00000418897 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 322; Involved in transcriptional regulation as an activator | 0.501 |
FBXL19 | ZNF518B | ENSP00000369666 | ENSP00000317614 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 518B; May be involved in transcriptional regulation | 0.501 |
KDM2A | UBC | ENSP00000432786 | ENSP00000344818 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | ubiquitin C | 0.740 |
KDM2A | UTY | ENSP00000432786 | ENSP00000328939 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) | 0.615 |
KDM2A | ZNF322 | ENSP00000432786 | ENSP00000418897 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 322; Involved in transcriptional regulation as an activator | 0.501 |
KDM2A | ZNF518B | ENSP00000432786 | ENSP00000317614 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 518B; May be involved in transcriptional regulation | 0.501 |
KDM2B | UBC | ENSP00000366271 | ENSP00000344818 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | ubiquitin C | 0.514 |
KDM2B | UTY | ENSP00000366271 | ENSP00000328939 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) | 0.615 |
KDM2B | ZNF322 | ENSP00000366271 | ENSP00000418897 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 322; Involved in transcriptional regulation as an activator | 0.501 |
KDM2B | ZNF518B | ENSP00000366271 | ENSP00000317614 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 518B; May be involved in transcriptional regulation | 0.501 |
PTPN23 | UBC | ENSP00000265562 | ENSP00000344818 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | ubiquitin C | 0.958 |
PTPN23 | ZNF322 | ENSP00000265562 | ENSP00000418897 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 322; Involved in transcriptional regulation as an activator | 0.476 |
PTPN23 | ZNF518B | ENSP00000265562 | ENSP00000317614 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 518B; May be involved in transcriptional regulation | 0.476 |
SEC23IP | UBC | ENSP00000358071 | ENSP00000344818 | SEC23 interacting protein; Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P) | ubiquitin C | 0.795 |
SEC23IP | ZNF518B | ENSP00000358071 | ENSP00000317614 | SEC23 interacting protein; Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P) | zinc finger protein 518B; May be involved in transcriptional regulation | 0.661 |