node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APOA1 | APOL1 | ENSP00000236850 | ENSP00000317674 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | apolipoprotein L, 1 | 0.977 |
APOA1 | HPR | ENSP00000236850 | ENSP00000441828 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | haptoglobin-related protein | 0.975 |
APOA1 | SP1 | ENSP00000236850 | ENSP00000329357 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | 0.921 |
APOL1 | APOA1 | ENSP00000317674 | ENSP00000236850 | apolipoprotein L, 1 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | 0.977 |
APOL1 | CD2AP | ENSP00000317674 | ENSP00000352264 | apolipoprotein L, 1 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | 0.610 |
APOL1 | CDC23 | ENSP00000317674 | ENSP00000378350 | apolipoprotein L, 1 | cell division cycle 23 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | 0.546 |
APOL1 | COMT | ENSP00000317674 | ENSP00000354511 | apolipoprotein L, 1 | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | 0.683 |
APOL1 | HPR | ENSP00000317674 | ENSP00000441828 | apolipoprotein L, 1 | haptoglobin-related protein | 0.956 |
APOL1 | INF2 | ENSP00000317674 | ENSP00000376410 | apolipoprotein L, 1 | inverted formin, FH2 and WH2 domain containing; Severs actin filaments and accelerates their polymerization and depolymerization (By similarity) | 0.684 |
APOL1 | MYH9 | ENSP00000317674 | ENSP00000216181 | apolipoprotein L, 1 | myosin, heavy chain 9, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping | 0.721 |
APOL1 | NPHS2 | ENSP00000317674 | ENSP00000356587 | apolipoprotein L, 1 | nephrosis 2, idiopathic, steroid-resistant (podocin); Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton | 0.606 |
APOL1 | PLCE1 | ENSP00000317674 | ENSP00000260766 | apolipoprotein L, 1 | phospholipase C, epsilon 1 | 0.608 |
APOL1 | SP1 | ENSP00000317674 | ENSP00000329357 | apolipoprotein L, 1 | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | 0.664 |
CD2AP | APOL1 | ENSP00000352264 | ENSP00000317674 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | apolipoprotein L, 1 | 0.610 |
CD2AP | INF2 | ENSP00000352264 | ENSP00000376410 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | inverted formin, FH2 and WH2 domain containing; Severs actin filaments and accelerates their polymerization and depolymerization (By similarity) | 0.755 |
CD2AP | NPHS2 | ENSP00000352264 | ENSP00000356587 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | nephrosis 2, idiopathic, steroid-resistant (podocin); Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton | 0.998 |
CD2AP | PLCE1 | ENSP00000352264 | ENSP00000260766 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | phospholipase C, epsilon 1 | 0.747 |
CDC23 | APOL1 | ENSP00000378350 | ENSP00000317674 | cell division cycle 23 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | apolipoprotein L, 1 | 0.546 |
COMT | APOL1 | ENSP00000354511 | ENSP00000317674 | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | apolipoprotein L, 1 | 0.683 |
HPR | APOA1 | ENSP00000441828 | ENSP00000236850 | haptoglobin-related protein | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | 0.975 |