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STRINGSTRING
SP1 SP1 APOA1 APOA1 HPR HPR CDC23 CDC23 APOL1 APOL1 COMT COMT MYH9 MYH9 PLCE1 PLCE1 INF2 INF2 CD2AP CD2AP NPHS2 NPHS2
"APOL1" - apolipoprotein L, 1 in Homo sapiens
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
APOL1apolipoprotein L, 1 (414 aa)    
Predicted Functional Partners:
APOA1
apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (267 aa)
        score_image score_image score_image   0.977
HPR
haptoglobin-related protein (348 aa)
          score_image score_image   0.956
MYH9
myosin, heavy chain 9, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (1960 aa)
            score_image   0.721
INF2
inverted formin, FH2 and WH2 domain containing; Severs actin filaments and accelerates their polymerization and depolymerization (By similarity) (1249 aa)
            score_image   0.684
COMT
catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (271 aa)
            score_image   0.683
SP1
Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] (785 aa)
            score_image   0.664
CD2AP
CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (639 aa)
            score_image   0.610
PLCE1
phospholipase C, epsilon 1 (2302 aa)
            score_image   0.608
NPHS2
nephrosis 2, idiopathic, steroid-resistant (podocin); Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton (383 aa)
            score_image   0.606
CDC23
cell division cycle 23 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains (597 aa)
        score_image       0.546
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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