node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000263620 | SNAP23 | ENSP00000464383 | ENSP00000249647 | Uncharacterized protein | synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion | 0.993 |
ENSG00000263620 | SNAP25 | ENSP00000464383 | ENSP00000254976 | Uncharacterized protein | synaptosomal-associated protein, 25kDa | 0.927 |
ENSG00000263620 | STX4 | ENSP00000464383 | ENSP00000317714 | Uncharacterized protein | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | 0.998 |
ENSG00000263620 | STX6 | ENSP00000464383 | ENSP00000258301 | Uncharacterized protein | syntaxin 6; Involved in intracellular vesicle trafficking | 0.877 |
ENSG00000263620 | STXBP3 | ENSP00000464383 | ENSP00000359025 | Uncharacterized protein | syntaxin binding protein 3; Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity) | 0.906 |
ENSG00000263620 | STXBP4 | ENSP00000464383 | ENSP00000365530 | Uncharacterized protein | syntaxin binding protein 4; Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity) | 0.607 |
ENSG00000263620 | VAMP7 | ENSP00000464383 | ENSP00000262640 | Uncharacterized protein | vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.828 |
SNAP23 | ENSG00000263620 | ENSP00000249647 | ENSP00000464383 | synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion | Uncharacterized protein | 0.993 |
SNAP23 | STX4 | ENSP00000249647 | ENSP00000317714 | synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | 0.999 |
SNAP23 | STX6 | ENSP00000249647 | ENSP00000258301 | synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion | syntaxin 6; Involved in intracellular vesicle trafficking | 0.986 |
SNAP23 | STXBP3 | ENSP00000249647 | ENSP00000359025 | synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion | syntaxin binding protein 3; Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity) | 0.993 |
SNAP23 | STXBP4 | ENSP00000249647 | ENSP00000365530 | synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion | syntaxin binding protein 4; Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity) | 0.610 |
SNAP23 | VAMP2 | ENSP00000249647 | ENSP00000314214 | synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion | vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.999 |
SNAP23 | VAMP3 | ENSP00000249647 | ENSP00000054666 | synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion | vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | 0.999 |
SNAP23 | VAMP7 | ENSP00000249647 | ENSP00000262640 | synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion | vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.999 |
SNAP23 | VAMP8 | ENSP00000249647 | ENSP00000263864 | synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion | vesicle-associated membrane protein 8; SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells [...] | 0.999 |
SNAP25 | ENSG00000263620 | ENSP00000254976 | ENSP00000464383 | synaptosomal-associated protein, 25kDa | Uncharacterized protein | 0.927 |
SNAP25 | STX4 | ENSP00000254976 | ENSP00000317714 | synaptosomal-associated protein, 25kDa | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | 0.999 |
SNAP25 | STX6 | ENSP00000254976 | ENSP00000258301 | synaptosomal-associated protein, 25kDa | syntaxin 6; Involved in intracellular vesicle trafficking | 0.967 |
SNAP25 | STXBP3 | ENSP00000254976 | ENSP00000359025 | synaptosomal-associated protein, 25kDa | syntaxin binding protein 3; Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity) | 0.603 |