node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDNF | EGR3 | ENSP00000414303 | ENSP00000318057 | brain-derived neurotrophic factor | early growth response 3; Probable transcription factor involved in muscle spindle development | 0.866 |
BDNF | NRG1 | ENSP00000414303 | ENSP00000349275 | brain-derived neurotrophic factor | neuregulin 1 | 0.912 |
BDNF | RHOA | ENSP00000414303 | ENSP00000400175 | brain-derived neurotrophic factor | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.503 |
EGR3 | BDNF | ENSP00000318057 | ENSP00000414303 | early growth response 3; Probable transcription factor involved in muscle spindle development | brain-derived neurotrophic factor | 0.866 |
EGR3 | FASLG | ENSP00000318057 | ENSP00000356694 | early growth response 3; Probable transcription factor involved in muscle spindle development | Fas ligand (TNF superfamily, member 6); Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects | 0.917 |
EGR3 | GABRA4 | ENSP00000318057 | ENSP00000264318 | early growth response 3; Probable transcription factor involved in muscle spindle development | gamma-aminobutyric acid (GABA) A receptor, alpha 4; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel | 0.916 |
EGR3 | IL2 | ENSP00000318057 | ENSP00000226730 | early growth response 3; Probable transcription factor involved in muscle spindle development | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.921 |
EGR3 | NAB2 | ENSP00000318057 | ENSP00000300131 | early growth response 3; Probable transcription factor involved in muscle spindle development | NGFI-A binding protein 2 (EGR1 binding protein 2); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity) | 0.923 |
EGR3 | NFATC1 | ENSP00000318057 | ENSP00000327850 | early growth response 3; Probable transcription factor involved in muscle spindle development | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells | 0.919 |
EGR3 | NFATC2 | ENSP00000318057 | ENSP00000379330 | early growth response 3; Probable transcription factor involved in muscle spindle development | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.987 |
EGR3 | NFATC3 | ENSP00000318057 | ENSP00000300659 | early growth response 3; Probable transcription factor involved in muscle spindle development | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 | 0.941 |
EGR3 | NRG1 | ENSP00000318057 | ENSP00000349275 | early growth response 3; Probable transcription factor involved in muscle spindle development | neuregulin 1 | 0.859 |
EGR3 | RHOA | ENSP00000318057 | ENSP00000400175 | early growth response 3; Probable transcription factor involved in muscle spindle development | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.904 |
FASLG | EGR3 | ENSP00000356694 | ENSP00000318057 | Fas ligand (TNF superfamily, member 6); Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects | early growth response 3; Probable transcription factor involved in muscle spindle development | 0.917 |
FASLG | IL2 | ENSP00000356694 | ENSP00000226730 | Fas ligand (TNF superfamily, member 6); Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.501 |
FASLG | NFATC1 | ENSP00000356694 | ENSP00000327850 | Fas ligand (TNF superfamily, member 6); Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells | 0.919 |
FASLG | NFATC2 | ENSP00000356694 | ENSP00000379330 | Fas ligand (TNF superfamily, member 6); Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.925 |
FASLG | NFATC3 | ENSP00000356694 | ENSP00000300659 | Fas ligand (TNF superfamily, member 6); Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 | 0.984 |
FASLG | RHOA | ENSP00000356694 | ENSP00000400175 | Fas ligand (TNF superfamily, member 6); Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.673 |
GABRA4 | EGR3 | ENSP00000264318 | ENSP00000318057 | gamma-aminobutyric acid (GABA) A receptor, alpha 4; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel | early growth response 3; Probable transcription factor involved in muscle spindle development | 0.916 |