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STRINGSTRING
NRG1 NRG1 BDNF BDNF NFATC3 NFATC3 RHOA RHOA EGR3 EGR3 NFATC2 NFATC2 GABRA4 GABRA4 FASLG FASLG NFATC1 NFATC1 IL2 IL2 NAB2 NAB2
"EGR3" - early growth response 3 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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from curated databases
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experimentally determined
Predicted Interactions
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textmining
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protein homology
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Score
EGR3early growth response 3; Probable transcription factor involved in muscle spindle development (387 aa)    
Predicted Functional Partners:
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (925 aa)
          score_image score_image   0.987
NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (1075 aa)
          score_image score_image   0.941
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity) (525 aa)
        score_image   score_image   0.923
IL2
interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells (153 aa)
          score_image score_image   0.921
NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (930 aa)
          score_image score_image   0.919
FASLG
Fas ligand (TNF superfamily, member 6); Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects (281 aa)
          score_image score_image   0.917
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (554 aa)
            score_image   0.916
RHOA
ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] (193 aa)
        score_image   score_image   0.904
BDNF
brain-derived neurotrophic factor (329 aa)
            score_image   0.866
NRG1
neuregulin 1 (645 aa)
            score_image   0.859
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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