node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIMP2 | FUBP3 | ENSP00000223029 | ENSP00000318177 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | 0.832 |
AIMP2 | UBC | ENSP00000223029 | ENSP00000344818 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor | ubiquitin C | 0.993 |
FGF9 | FUBP3 | ENSP00000371790 | ENSP00000318177 | fibroblast growth factor 9 (glia-activating factor); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | 0.842 |
FUBP3 | AIMP2 | ENSP00000318177 | ENSP00000223029 | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor | 0.832 |
FUBP3 | FGF9 | ENSP00000318177 | ENSP00000371790 | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | fibroblast growth factor 9 (glia-activating factor); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors | 0.842 |
FUBP3 | GAPDH | ENSP00000318177 | ENSP00000229239 | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.806 |
FUBP3 | HNRNPF | ENSP00000318177 | ENSP00000338477 | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | heterogeneous nuclear ribonucleoprotein F; Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state | 0.778 |
FUBP3 | NUDT21 | ENSP00000318177 | ENSP00000300291 | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | nudix (nucleoside diphosphate linked moiety X)-type motif 21; Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3’-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3’-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5’-UGUA-3’ elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export | 0.615 |
FUBP3 | NUP62 | ENSP00000318177 | ENSP00000305503 | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | nucleoporin 62kDa; Essential component of the nuclear pore complex. The N- terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex | 0.644 |
FUBP3 | POLDIP3 | ENSP00000318177 | ENSP00000252115 | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | polymerase (DNA-directed), delta interacting protein 3 | 0.605 |
FUBP3 | PUF60 | ENSP00000318177 | ENSP00000434359 | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | poly-U binding splicing factor 60KDa; DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group [...] | 0.888 |
FUBP3 | QKI | ENSP00000318177 | ENSP00000355094 | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | QKI, KH domain containing, RNA binding | 0.746 |
FUBP3 | UBC | ENSP00000318177 | ENSP00000344818 | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | ubiquitin C | 0.849 |
GAPDH | FUBP3 | ENSP00000229239 | ENSP00000318177 | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | 0.806 |
GAPDH | UBC | ENSP00000229239 | ENSP00000344818 | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | ubiquitin C | 0.999 |
HNRNPF | FUBP3 | ENSP00000338477 | ENSP00000318177 | heterogeneous nuclear ribonucleoprotein F; Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | 0.778 |
HNRNPF | NUDT21 | ENSP00000338477 | ENSP00000300291 | heterogeneous nuclear ribonucleoprotein F; Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state | nudix (nucleoside diphosphate linked moiety X)-type motif 21; Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3’-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3’-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5’-UGUA-3’ elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export | 0.914 |
HNRNPF | UBC | ENSP00000338477 | ENSP00000344818 | heterogeneous nuclear ribonucleoprotein F; Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state | ubiquitin C | 0.993 |
NUDT21 | FUBP3 | ENSP00000300291 | ENSP00000318177 | nudix (nucleoside diphosphate linked moiety X)-type motif 21; Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3’-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3’-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5’-UGUA-3’ elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression | 0.615 |
NUDT21 | HNRNPF | ENSP00000300291 | ENSP00000338477 | nudix (nucleoside diphosphate linked moiety X)-type motif 21; Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3’-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3’-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5’-UGUA-3’ elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export | heterogeneous nuclear ribonucleoprotein F; Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state | 0.914 |