FAM46A protein (Homo sapiens) - STRING network view

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Score

FAM46A

family with sequence similarity 46, member A (442 aa)

Predicted Functional Partners:

ELOVL4

0.867

UBC

0.730

PLEKHA8

0.556

SMCR7L

0.505

FDXR

0.500

TAMM41

0.492

STRBP

0.487

CHI3L1

0.433

PAPD5

0.425

ZCCHC6

0.421

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHI3L1	FAM46A	ENSP00000255409	ENSP00000318298	chitinase 3-like 1 (cartilage glycoprotein-39); Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment	family with sequence similarity 46, member A	0.433
ELOVL4	FAM46A	ENSP00000358831	ENSP00000318298	ELOVL fatty acid elongase 4; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24-0 and C26-0 acyl-CoAs. Seems to represent a photoreceptor- specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development	family with sequence similarity 46, member A	0.867
ELOVL4	UBC	ENSP00000358831	ENSP00000344818	ELOVL fatty acid elongase 4; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24-0 and C26-0 acyl-CoAs. Seems to represent a photoreceptor- specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development	ubiquitin C	0.417
FAM46A	CHI3L1	ENSP00000318298	ENSP00000255409	family with sequence similarity 46, member A	chitinase 3-like 1 (cartilage glycoprotein-39); Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment	0.433
FAM46A	ELOVL4	ENSP00000318298	ENSP00000358831	family with sequence similarity 46, member A	ELOVL fatty acid elongase 4; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24-0 and C26-0 acyl-CoAs. Seems to represent a photoreceptor- specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development	0.867
FAM46A	FDXR	ENSP00000318298	ENSP00000462972	family with sequence similarity 46, member A	ferredoxin reductase; Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver	0.500
FAM46A	PAPD5	ENSP00000318298	ENSP00000396995	family with sequence similarity 46, member A	PAP associated domain containing 5; Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion	0.425
FAM46A	PLEKHA8	ENSP00000318298	ENSP00000397947	family with sequence similarity 46, member A	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for [...]	0.556
FAM46A	SMCR7L	ENSP00000318298	ENSP00000327124	family with sequence similarity 46, member A	Smith-Magenis syndrome chromosome region, candidate 7-like; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Seems to have a key role in inhibiting DNM1L-induced mitochondrial fission	0.505
FAM46A	STRBP	ENSP00000318298	ENSP00000321347	family with sequence similarity 46, member A	spermatid perinuclear RNA binding protein; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I-C) RNA than to poly(dI-dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3’-UTR and adenovirus VA RNA (By similarity)	0.487
FAM46A	TAMM41	ENSP00000318298	ENSP00000273037	family with sequence similarity 46, member A	TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae); May be involved in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane (By similarity)	0.492
FAM46A	UBC	ENSP00000318298	ENSP00000344818	family with sequence similarity 46, member A	ubiquitin C	0.730
FAM46A	ZCCHC6	ENSP00000318298	ENSP00000365130	family with sequence similarity 46, member A	zinc finger, CCHC domain containing 6	0.421
FDXR	FAM46A	ENSP00000462972	ENSP00000318298	ferredoxin reductase; Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver	family with sequence similarity 46, member A	0.500
FDXR	UBC	ENSP00000462972	ENSP00000344818	ferredoxin reductase; Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver	ubiquitin C	0.663
PAPD5	FAM46A	ENSP00000396995	ENSP00000318298	PAP associated domain containing 5; Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion	family with sequence similarity 46, member A	0.425
PAPD5	SMCR7L	ENSP00000396995	ENSP00000327124	PAP associated domain containing 5; Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion	Smith-Magenis syndrome chromosome region, candidate 7-like; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Seems to have a key role in inhibiting DNM1L-induced mitochondrial fission	0.602
PAPD5	STRBP	ENSP00000396995	ENSP00000321347	PAP associated domain containing 5; Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion	spermatid perinuclear RNA binding protein; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I-C) RNA than to poly(dI-dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3’-UTR and adenovirus VA RNA (By similarity)	0.580
PAPD5	TAMM41	ENSP00000396995	ENSP00000273037	PAP associated domain containing 5; Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion	TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae); May be involved in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane (By similarity)	0.581
PLEKHA8	FAM46A	ENSP00000397947	ENSP00000318298	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for [...]	family with sequence similarity 46, member A	0.556

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