Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
HAGH HAGH DEF8 DEF8 SYDE1 SYDE1 SFSWAP SFSWAP LENG8 LENG8 PCID2 PCID2 SAMSN1 SAMSN1 CTPS2 CTPS2 CXADR CXADR CTPS1 CTPS1 RPS9 RPS9
"LENG8" - leukocyte receptor cluster in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LENG8leukocyte receptor cluster (LRC) member 8 (800 aa)    
Predicted Functional Partners:
PCID2
PCI domain containing 2 (399 aa)
         score_image   score_image   0.910
RPS9
ribosomal protein S9 (194 aa)
             score_image   0.693
CTPS2
CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (586 aa)
             score_image   0.670
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1; Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity) (373 aa)
             score_image   0.640
CXADR
coxsackie virus and adenovirus receptor; Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN (365 aa)
             score_image   0.608
DEF8
differentially expressed in FDCP 8 homolog (mouse) (512 aa)
             score_image   0.544
HAGH
hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (308 aa)
             score_image   0.501
CTPS1
CTP synthase 1; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (591 aa)
             score_image   0.485
SFSWAP
splicing factor, suppressor of white-apricot homolog (Drosophila); Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10 (951 aa)
       score_image     score_image   0.431
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans); GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (735 aa)
             score_image   0.422
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (49%)